Ambulatory monitoring of activity levels of individuals in the sub-acute stage following stroke: a case series
© Gage et al; licensee BioMed Central Ltd. 2007
Received: 13 December 2006
Accepted: 26 October 2007
Published: 26 October 2007
There is an important need to better understand the activities of individual patients with stroke outside of structured therapy since this activity is likely to have a profound influence on recovery. A case-study approach was used to examine the activity levels and associated physiological load of patients with stroke throughout a day.
Activities and physiologic measures were recorded during a continuous 8 hour period from 4 individuals in the sub-acute stage following stroke (ranging from 49 to 80 years old; 4 to 8 weeks post-stroke) in an in-patient rehabilitation hospital.
Both heart rate (p = 0.0207) and ventilation rate (p < 0.0001) increased as intensity of activity increased. Results revealed individual differences in physiological response to daily activities, and large ranges in physiological response measures during 'moderately' and 'highly' therapeutic activities.
Activity levels of individuals with stroke during the day were generally low, though task-related changes in physiologic measures were observed. Large variability in the physiological response to even the activities deemed to be greatest intensity suggests that inclusion of such extended measurement of physiologic measures may improve understanding of physiological profile that could guide elements of the physical therapy prescription.
Considerable effort in the rehabilitation process of patients with stroke is orientated towards addressing sensori-motor dysfunction [1, 2] and cognitive deficits [2, 3]. Although the majority of patients with stroke have concomitant cardiovascular disease, and as such can benefit from aerobic exercise training, the effects of such exercise among these patients is only beginning to be considered in the literature [4, 5]. A recent meta-analysis which included seven randomized controlled trials examining the efficacy of aerobic exercise training among patients with stroke reported that there is good evidence to support the use of aerobic exercise among patients with mild and moderate stroke for improving aerobic capacity . Studies that have examined the effects of exercise [7, 8] in sufficient dose and intensity have shown that improvements in cardiovascular fitness among individuals with stroke can be comparable to that of healthy, age-matched adults. The benefits of exercise for these individuals include improved cardiovascular and psychological status, and sensorimotor, strength, and endurance measures .
The potential importance of activity programs is heightened given the evidence to suggest that individuals with stroke are generally sedentary. Individuals who have had a stroke within the past 14 days and who reside in an acute care hospital spend more than 50% of the day lying in bed, 28% of the day sitting in bed, and 13% of the day engaged in functional activities; therapist contact accounted for only 5.2% of the patient's day . Earlier work reported that activity levels of individuals with stroke residing in a hospital stroke ward were low throughout the day, however the amount of time that had passed since the stroke was not reported . While this work provides some general insight into activity patterns there has been no research to examine daily activity levels and associated cardiorespiratory responses of patients with stroke at the sub-acute stage of recovery in a rehabilitation setting. Traditional rehabilitation programs that focus on improving ability to perform daily function are unlikely to adequately challenge the cardiovascular system of individuals with stroke. Patient heart rates have been shown to reach target ranges considered acceptable for conditioning programs during therapy; however, the length of time in the target range is very brief [5, 9]. The brevity of elevated heart rate during therapy, and the low percentage of the day engaged in the therapy program, combined, suggest that the cardiovascular challenge provided to individuals with stroke during a structured rehabilitation program is insufficient to maintain, let alone improve, cardiorespiratory capacity.
Gordon and colleagues  suggested, based on previous work by Palmer-McLean and Harbst, and others, that to obtain a cardiovascular training effect, individuals with stroke need to perform cardiovascular exercise at 40% to 70% of heart rate reserve, or 50% to 80% of maximum heart rate, for 20 to 60 minutes per day, 3 to 7 times per week, and that exercise may be performed in multiple 10-minute sessions. Individuals who have had a stroke do appear to benefit significantly from cardiovascular exercise [7–9], and it is clear that they receive very little, if any, cardiovascular benefit from activities during therapy . Clearly more research must be conducted to explore the efficacy and feasibility of cardiovascular exercise after stroke, with particular attention paid to the type and dose of exercise . However, the focus must also be directed to non-therapy related activities since such activities are likely to be an important determinant of the cardiorespiratory fitness profile of individual survivors of stroke. To date, there has been little information to indicate the type and intensity of activities that stroke patients are engaged in during the day when not in therapy. The activities engaged in outside of structured therapy sessions would potentially have a profound influence on the cardiorespiratory status in addition to being an important index of the changes in functional capacity occurring over the course of rehabilitation. The challenge of such work is to be able to assess both activity and the physiologic responses to be able to judge the potential therapeutic benefit of specific daily activities.
The objective of this study was to examine activity profiles and associated cardiorespiratory load of individuals in the sub-acute stage after stroke throughout a day using an ambulatory data collection system. We hypothesized that individual activity levels would not be of sufficient intensity or duration to elicit a cardiorespiratory training effect, even during structured therapy sessions. In addition, we addressed the relationship, within specific cases, between an activity-level classification (rated 0–4) with ambulatory recorded measures of physiological response to activity (heart rate, ventilation rate). We believe that information related to an individual's physiological response to specific activity (whether directly therapeutic or non-therapeutic activity) may be uniquely important for therapists when designing person-specific structured and unstructured activity programs for individuals with stroke.
Characteristics of the individual participants.
Date of Stroke*
Date of Testing*
Time from stroke to testing (months)
Location of stroke
Left interior capsule
Right pontine lacunar
Losartan HCTZ Plavix Nifedipine
Diazepam Glycerin Atorvastatin Heparin Sodium ASA
Plavix Rampril HCTZ Cardizem
CMSA leg score (adm/disch)
FIM (locomotion; adm/disch)
FIM (upper body; adm/disch)
Resting HR** (day of testing; bpm)
Lower limit target HR training zone (bpm)
Peak demonstrated HR
Peak demonstrated VO2 (ml/kg/min)
Amount of time in each activity category (AC) 
No samples; see text for explanation
Measures of Interest
To reflect periods of sustained HR elevation throughout the day, and the American Heart Association's scientific statement recommendations for exercise , we determined the mean HR across a 10 minute window (HR10), and serially advanced the window by 1-minute increments to construct a moving-average profile of the HR signal. We determined the individual's resting HR by finding the lowest 1-minute average HR during the collection period; a computer algorithm was used to find the lowest 1-minute average HR, and visual inspection confirmed this finding. Lower and upper limits of the HR target training zone were determined using the Karvonen formula  to provide conservative estimates of these limits. The lower limit of the cardiovascular training zone for each individual is noted in Table 1. We determined the total accumulated time that the individual's HR was within the target training zone, based on the HR10.
Previous work used a 0–4 point scale to categorize activity levels among individuals with stroke throughout the day (activity category, AC) . The same rating scale was used in the current study. Based on the activity descriptions recorded throughout the day, each period of different activity was assigned an activity level. For example, if the individual was sitting and resting (AC0) for a period of 3 minutes, after which he walked on a treadmill for 11 minutes (AC4), it was recorded that the individual performed an AC0 activity for 3 minutes and an AC4 activity for 11 minutes. For each of these two periods, e.g. 3 minutes and 11 minutes, average HR and VR values were calculated. To reflect continuous performance of an activity within a given AC, average HR and VR values were determined only if the activity was performed for 2 minutes or longer. Non-parametric methods were used to assess changes in HR and VR by AC. Kruskal-Wallis tests were used to assess changes in HR and VR with AC; individual Wilcoxon tests were used to explore significant differences between levels of AC.
Feasibility of ambulatory monitoring
All four participants reported that the LifeShirt vest was comfortable to wear under normal clothing throughout the day. Only one individual was able to put on the LifeShirt independently (participant S1; FIM (dressing upper body) score at discharge was 7; Table 1); the other three participants required assistance. Note that electrodes for ECG monitoring were positioned and adhered by the experimenter. None of the patients reported that wearing the device restricted or otherwise impaired their movements. There were no occurrences of system or sensor problems once the system was fitted to the subject (i.e. data were collected without disruption for the 8 hour period).
Heart rate, ventilation rate, and activity profiles: sample tracings
HR profile data gathered throughout the day indicated that the overall cardiorespiratory load was low for three of the four participants (S1, S2, S3) throughout most of the day. Including the periods of structured therapy, individuals' HRs were on average 16 bpm above their resting levels (range of 12 to 19 bpm above resting). The average HR for participant S4, including periods of structured therapy was 29 bpm above resting. However, this individuals peak demonstrated VO2 (8.9 mlO2/kg/min) was 30% lower than the average VO2 of the other three individuals, which suggests that this individual functioned at a higher percentage of his cardiovascular capacity when performing activities of daily living. There were important activity-related differences within each participant. To highlight these differences, a sample profile of HR and VR for S1 is presented in Figure 2, with the synchronized record of the individual's functional and physical activities. This individual's data was chosen because he demonstrated the most robust heart rate response to his physical therapy session, which may be a function of his higher FIM score results (overall score, and locomotion and upper body subscale scores).
Case 1 (S1)
Case 2 (S2)
This individual demonstrated an average heart rate throughout the day of 86 bpm (with the exception of two periods; during physical therapy and during a self-directed walking program; see below), an increase of 21% relative to his resting HR of 71 bpm. However, his HR during his physical therapy session was 88 bpm, an increase of only 2 bpm compared with his mean HR for the rest of the day, suggesting that S2 demonstrated no clear HR response to the physical therapy session. The only time during the day that this individual's HR increased notably was during a 50 minute period in the afternoon during which the individual was engaged in a self-directed walking and stretching program which was not prescribed by the physical therapist. His mean HR during this 50 minute period of self-directed activity was 98 bpm, an increase of 12 bpm, or 14%, compared with his average HR throughout the rest of the day (including the period during physical therapy). It should be noted that the patient was not being monitoring by a therapist during this period, which occurred three hours after the end of his formal physical therapy session.
Case 3 (S3)
Similar to S2, and in contrast to S1, S3 demonstrated no clear HR response to his structured physical therapy session. This patient's average HR was 64 bpm during physical therapy, and 65 bpm throughout the remainder of the day. S3 demonstrated small increases in HR later in the testing session (at approximately hours 5 and 6 of testing), and these elevations in HR were of sufficient duration to possibly effect a cardiovascular training response (see Heart Rate: 10 minute moving average (HR10), below, and Figure 4). However, these increases in heart rate did not occur during any therapy session, but, rather, while walking to the speech therapy session, and when dressing later in the day. Interestingly, even when S3 reported resting during a 50 minute period in the morning following his physical therapy session, his average heart rate was 64 bpm, which is consistent with his average heart rate throughout the day. The individual was not directly observed during that time so it is not clear if the individual was truly 'resting' or was engaged in some nominal activity which may have elevated his HR (note: the participant reported that he was intending to lie down on his bed and rest; as such, privacy was appropriately provided by the research assistant, explaining why the participant was not directly observed during this period). These findings suggest that ambulatory monitoring of physiological parameters such as HR (as well as monitoring of kinematics) may lead to more reliable reporting not only of activity but also of the intensity of activity, when compared with self-reporting.
Case 4 (S4)
Similar to S1, S4 demonstrated a clear HR response during physical therapy. During this period, his mean HR was 111 bpm, and increase of 80% relative to his resting HR. However, as suggested earlier, S4 demonstrated peak VO2 was 30% lower than that of the other three participants, which suggests that very little physical activity was required to substantially challenge this patient's cardiovascular system. This suggestion is supported by findings which indicated a marked increase in heart rate when S4 was engaged in activities such as: standing, brief periods of walking, and extended periods of sitting while eating (increase in HR of 52% compared with resting HR); and engaged in occupational therapy (increase in HR of 47% compared with resting HR).
Heart rate: 10 minute moving average (HR10)
Figure 4 shows the HR10 profile for each individual. The heavily shaded sections of each response profile represents the period during which the individual's HR10 reached the cardiovascular training zone. The HR10 measures for 3 of the 4 participants suggest that these three individuals exceeded the minimum threshold and may have, according to the American Heart Association Scientific Statement, experienced a cardiovascular training response associated with the activities they engaged in at various times throughout the day. Participants S1, S3, and S4 demonstrated HR10 responses that exceeded the minimum threshold for their training zones for totals of: 63, 38, and 253 minutes, respectively. At no point during the day did the HR10 of subject S2 reach this minimum threshold. Of each patient's total time in the cardiovascular training zone, 83%, 0%, and 32% of this time was associated with a structured physical therapy session for participants S1, S3, and S4, respectively. The large amount of time spent by S4 in the cardiovascular training zone associated with activities such as sitting and eating, may be explained by this individual's very low cardiovascular fitness. The relatively small amount of time spent by S3 in the cardiovascular training zone might be related to his lower levels of disability as indicated by his NIHSS and FIM measures (Table 1), in addition to his relatively higher peak VO2. In addition, it appears that S3 was not sufficiently challenged during his physical therapy session, relative to his own cardiovascular fitness level.
Heart rate (HR) and ventilation rate (VR): relationship to activity level
The purpose of this study was to: 1) examine the physical activity levels and associated cardiorespiratory responses of individuals with stroke during normal daily activities which included their structured physical therapy sessions, and 2) examine the relationship between a previously reported activity level classification with measured physiological responses to daily activity (heart rate, ventilation rate). We used a commercially available wearable ambulatory physiological monitoring system. This study linked measured physiologic change with specific daily activities including activities associated with structured rehabilitation sessions, as well as the activities and times when the individuals were not in therapy.
Importantly, the findings of this study provide direct physiologic evidence to support the suggestion that individuals with stroke are generally inactive throughout the day, which is consistent with observational reports in the literature [10, 11]. Little information regarding the activity patterns of individuals with stroke throughout the day is available. Though Bernhardt et al.  demonstrated that individuals in the acute phase of recovery following stroke are generally inactive according to a subjective scale rating the therapeutic level of various activities from 0 (inactive) to 4 (highly therapeutic), the findings of the current study suggest that, among individuals in the subacute stage of recovery, even activities included in the categories of highest therapeutic relevance (e.g. walking) may not load the cardiorespiratory system sufficiently to elicit a training effect. Although both HR and VR generally increased with the subjectively rated AC, large individual differences in these relationships, as well as large ranges in the measures of HR and VR within each AC, for each individual. These findings suggest that physiological load cannot be assessed directly from AC. For example, S1 and S4 demonstrated marked differences in mean HR and VR across the AC levels (Figure 5). S2 demonstrated similar differences across AC levels 1, 3, and 4, though both HR and VR were greater for AC0 than for AC1. S2 spent only 2% of the testing session in the AC0 category (see Table 1), and this period may have been marked by an elevated HR and VR for reasons other than physical activity (i.e. anxiety or other stress). S3 demonstrated no apparent change in HR or VR across the AC categories. In addition to individual differences in the physiological response to activity across the individuals, each patient demonstrated large ranges in the measures of HR and VR within each AC, particularly for AC3 and AC4. For S1, HR ranged between 91 and 102 bpm during AC3 activities, and between 90 and 130 during AC4 activities. For S2, HR ranged between 74 and 95 bpm during AC3 activities, and between 81 and 101 bpm during AC4 activities. The other two participants demonstrated similar HR responses. The average HR range during AC3 activities across the four individuals was 18 bpm; during AC4 activities, the average HR range was 32 bpm. Furthermore, S1 demonstrated HR responses adequate to elicit a physiological training effect (i.e. HR greater than the minimum threshold for a training effect according to the American Heart Association scientific statement) for less than 50% of the time this individual spent in AC4 'highly therapeutic' activities. During AC3 'moderately therapeutic' activities, this same individual's HR did not enter the training zone at all. Clearly, an observational measure of activity level does not adequately describe the physiological load, or potential benefit, of individual activities, and addition of physiological parameters such as HR or VR are needed to assess the physiological load of activity for individuals. Ambulatory monitoring of physiological load during activity provides the capacity to assess the aerobic challenge associated with activity and adjust the intensity of activity on a person-to-person basis.
While previous work has inferred the therapeutic relevance of physical activity based on the expert opinion of experienced clinicians, the current study has added direct physiological measurement of the physiological load the activity to the understanding of the (potential) health benefits associated with the activity. This additional information available through the use of the physiologic monitoring has provided three important insights. First, and consistent with work by MacKay-Lyons and Makrides , the physiological load experienced by individuals during structured therapy sessions may not be sufficient to elicit a cardiovascular benefit or training effect. Second, tremendous individual differences exist in the individual's physiological response to physical activity during therapy and throughout the day. Third, even during activities which are deemed by expert opinion to be highly therapeutic, large ranges in measures of physiological response (i.e. heart rate, ventilation rate) suggest that these activities do not necessarily provide a cardiovascular training effect. These insights confirm that it is imperative that ambulatory physiological measurement systems (i.e. wearable heart rate monitors) be used during physical therapy sessions not only to ensure the safety of the patient, but also (and likely more commonly) to ensure that the patient is engaged with sufficient intensity to challenge the cardiovascular system to the point of training effect. Furthermore, the findings of the current study underscore the need to better understand the nature of the physical activities engaged in by individuals throughout the day, such as the type of activity, the duration that specific activities are performed, and the intensity of the activity in terms of the cardiorespiratory response. Ambulatory physiological monitoring of individuals with stroke throughout the day may provide a method of influencing individual activity profiles on a day-to-day basis and eventually via a method of real-time monitoring and prompting.
Activities engaged in by the individuals throughout the day were categorized according to a previously established method using observation techniques to infer therapeutic value of physiologic loads associated with activity . The results suggested that the four participants in the current study were engaged in activity that was deemed non-therapeutic for, on average, slightly more than 50% (range of 23 to 65%) of the day, which is consistent with the report of Bernhardt and colleagues . The individuals in the previous study spent 28% of the day engaged in minimally therapeutic activities (i.e. sitting supported out of bed). The individuals in the current study did not perform any activities that were considered to be in the minimally therapeutic category. Therefore, it seems that the individuals in the current study had a greater volume and extent of activity in categories of higher therapeutic relevance due, in part, to their higher functional capacity. For example, they were all capable of sitting unsupported, and therefore spent a larger percentage of the day, according to this scale, engaged in moderately and highly therapeutic activity (50% of the day, versus 12.8% in the previous study). The previous work by Bernhardt  examined individuals with stroke at an early stage of recovery while the current study explored activity profiles of in-patients who were later in their stage of recovery (four to eight weeks after stroke). It is unlikely that individuals able to ambulate independently (with aids), such as those who participated in the current study, would find sitting unsupported substantially challenging from a sensorimotor perspective or in terms of cardiovascular load, and therefore the recovery time differences may explain the increase in activities which, according to this scale, would be considered therapeutically-relevant if using the activity scale. These findings suggest that development of an alternate activity level scale designed specifically for individuals at later stages of recovery following stroke might be useful and more discriminative in assessing the physiological challenge of various daily activities.
A limitation of this study was sample size; a research assistant was required to spend 8 to 9 hours observing each participant, limiting the feasible number of participants, and limiting data collections to a single day. Therefore, the sample of participants included individuals who varied greatly in age and neurologic impairment, in order to explore in a case-study approach the level of activity among patients with stroke, and the relationship between activity level classification and continuously sampled physiological response. The development of movement assessment capability (e.g. accelerometers) and validation of the discriminative capacity of such measurements (to distinguish movement profiles) is essential to improve the practical application of this approach to remove time and cost constraints imposed by the necessity of a research assistant to manually document participant activities all day long. Such remote measurement of movement, as opposed to relying on observation, would also help to counter limitations associated with privacy and observation. In addition, it is possible that the participants may have altered their normal daily activities, or altered the level of effort provided during various tasks as a result of being observed throughout the day. It should be noted, however, that one might have anticipated an increase in relative activity under such a scenario and in the case of the present individuals they were characterized by relatively low levels of daily activity.
This study confirms and extends the results of previous research providing a detailed view of the activity patterns of individual patients with stroke and the associated physiological response throughout the day. First, the activity level of individuals with stroke during structured therapy sessions may not be of sufficient physiological challenge to elicit a cardiovascular training effect. Second, they appear to be relatively inactive throughout the day, and simple observation of their physical activity may not assess the therapeutic relevance of the activity. Third, we have associated a measure of physiological challenge with the individual's activities of daily living. Future research will examine methods of influencing the activity level of individuals with stroke in the rehabilitation hospital and community. Incumbent in that research will be the development of technology which will associate kinematic measurements with physiologic data. Such developments will facilitate inclusion of a larger sample size by autonomously providing a context of activity to the physiologic measure, reducing the cost of data gathering and enhancing feasibility. Data acquisition systems built on emerging sensor technologies will provide the understanding of the individual's activity necessary for meaningful interpretation of the physiologic response to activity throughout the day (and night). Information related to activity obtained at times outside of structured therapy sessions may serve to provide important insight regarding the individual's status not otherwise available to the therapist. In addition, these developments will allow precise measurement of function and intensity of activity in the community, promoting evidence-based therapeutic practice following discharge from the daily therapy program or rehabilitation hospital.
We acknowledge the support of the Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council, Heart and Stroke Foundation of Ontario, and Physiotherapy Foundation of Canada. We acknowledge the support of Toronto Rehabilitation Institute who receives funding under the Provincial Rehabilitation Research Program from the Ministry of Health and Long Term Care in Ontario. Vivometrics provided the LifeShirt data acquisition system. We appreciate the assistance of Mathew Machina, Susan Czyzo, and Michael Sexsmith in collection of data.
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