Effects of unilateral robotic limb loading on gait characteristics in subjects with chronic stroke
- Ira Khanna†1,
- Anindo Roy†2, 3, 4Email author,
- Mary M Rodgers†1,
- Hermano I Krebs†2, 4, 5,
- Richard M Macko1, 3, 4, 6 and
- Larry W Forrester†1, 3, 4
© Khanna et al; licensee BioMed Central Ltd. 2010
Received: 6 November 2009
Accepted: 21 May 2010
Published: 21 May 2010
Hemiparesis after stroke often leads to impaired ankle motor control that impacts gait function. In recent studies, robotic devices have been developed to address this impairment. While capable of imparting forces to assist during training and gait, these devices add mass to the paretic leg which might encumber patients' gait pattern. The purpose of this study was to assess the effects of the added mass of one of these robots, the MIT's Anklebot, while unpowered, on gait of chronic stroke survivors during overground and treadmill walking.
Nine chronic stroke survivors walked overground and on a treadmill with and without the anklebot mounted on the paretic leg. Gait parameters, interlimb symmetry, and joint kinematics were collected for the four conditions. Repeated-measures analysis of variance (ANOVA) tests were conducted to examine for possible differences across four conditions for the paretic and nonparetic leg.
The added inertia and friction of the unpowered anklebot had no statistically significant effect on spatio-temporal parameters of gait, including paretic and nonparetic step time and stance percentage, in both overground and treadmill conditions. Noteworthy, interlimb symmetry as characterized by relative stance duration was greater on the treadmill than overground regardless of loading conditions. The presence of the unpowered robot loading reduced the nonparetic knee peak flexion on the treadmill and paretic peak dorsiflexion overground (p < 0.05).
Our results suggest that for these subjects the added inertia and friction of this backdriveable robot did not significantly alter their gait pattern.
Over 795,000 strokes occur in the United States each year . Of those individuals that survive, approximately two-thirds have residual motor deficits, including impaired gait . Lower extremity hemiparesis has been shown to reduce walking speed and endurance [2–6] as well as gait parameters such as step length [4, 7] and stance duration . Studies have shown that impaired swing initiation, abbreviated paretic single limb support [9, 10], decreased hip flexion, increased knee flexion, and increased ankle plantarflexion at toe off  are all characteristic of hemiparetic gait.
Rehabilitation intervention has demonstrated significant potential for improving motor function and gait [3, 11]. Traditional models of gait rehabilitation often employ task-oriented exercises such as stepping and weight shifting  as well as manual stretching to increase range of motion and strength training . Recent studies have shown that practice over a treadmill can improve cardiovascular fitness and ambulatory performance in individuals with hemiparetic gait [13–16] including improved interlimb symmetry , cadence and gait velocity [3, 14, 17, 18]. A recent Cochrane Report has reported that along with treadmill training, there is evidence to suggest electromechanical gait training may improve independent walking .
The Cochrane Report includes results observed in trials with two devices, namely the Gait Trainer I and the Lokomat®. More recent studies have focused on robotic devices for the ankle joint  to address the problem of drop foot that occurs during hemiparetic gait . For this class of robotic devices, a possible confounding factor resulting from wearing the device during walking is the added mass which might encumber patients' ability to move, especially their leg during walking. Noble and Prentice found that adding a 2 kg weight to the non-dominant leg of young adults resulted in increased knee and hip flexion during the swing phase as well as reduced plantarflexion at toe off of the weighted limb . Since individuals with hemiparesis have asymmetric gait, the addition of asymmetric loading to the paretic limb may further increase asymmetry and affect gait kinematics. For example, one study of individuals with post-stroke hemiparesis showed that adding a unilateral weight to the nonparetic leg increased hip and knee excursions in the paretic limb .
Here we examined the effects of asymmetric or unilateral loading of the paretic limb during task-oriented gait therapy. Specifically, we sought to assess the effects of the added inertia and friction of unpowered ankle robot on gait parameters, interlimb symmetry, and lower extremity joint kinematics in chronic stroke survivors. We examined these effects in two common rehabilitation training scenarios: walking over ground (OG) and treadmill (TM) training. We hypothesized that loading the paretic limb with the robot would change bilateral joint kinematics.
Ten chronic stage stroke survivors (4 males and 6 females) were recruited through the Veterans Affairs (VA) Maryland Exercise and Robotics Center of Excellence and the University of Maryland (UM) Claude D. Pepper Older Americans Independence Center in Baltimore, Maryland. Participants met the following inclusion criteria: a) at least 6 months post ischemic stroke with residual hemiparetic gait, b) able to walk on a treadmill, and c) had a score greater than a 23 on the mini mental state exam (MMSE)  and able to follow two step commands. Individuals with unstable angina, congestive heart failure within the last 3 months, major orthopedic or chronic pain, poorly controlled hypertension, recent hospitalization for severe disease or surgery, a history of severe ankle injury or severe receptive aphasia were excluded from the study. The study was approved by the VA Rehabilitation Research and Development (RR&D) Committee and UM Institutional Review Board, and Massachusetts Institute of Technology's Committee on the Use of Humans as Experimental Subjects (COUHES). All participants signed informed consent and underwent medical evaluations to establish eligibility.
Clinical assessments included a medical history, MMSE, and active and passive ranges of motion (AROM and PROM)  of the paretic hip, knee, and ankle joints. In addition, spasticity for the paretic knee and ankle was assessed using the Modified Ashworth Spasticity (MAS) Scale . Manual Muscle Testing (MMT)  was performed for the hip, knee and ankle flexor and extensor muscle groups. Body mass index (BMI) was also calculated for each participant.
Two separate sessions were scheduled to evaluate baseline walking performance over ground and on the treadmill. The first session assessed participants' ability to walk independently overground (OG) and on the treadmill (TM). The session began with three 10-meter walks to determine participants' self-selected floor walking velocity using an instrumented gait mat (GAITRite®, CIR Systems, Havertown, Pa). We determined and attempted to control the speed for all the following conditions from this self-selected floor walking velocity. Participants, then, walked OG and then on a TM (6 trials per condition with TM trials lasting 15 seconds each). To minimize fatigue, participants were asked to return for a second session two days later when they repeated OG and then TM walking while wearing the unpowered anklebot on the paretic leg ("OGR" and "TMR" conditions, respectively). When walking on the treadmill, individuals were instructed to hold the handrails. Optimal fitting of the anklebot was established for each participant prior to walking to minimize its slippage during gait and to maximize subject comfort. Optotrak® motion analysis system (Northern Digital Inc., Waterloo, Canada) was utilized along with the MotionMonitor™ computer software to collect gait kinematics. Light emitting diodes (LED) were attached to the sacrum and the posterior mid-thigh, the posterior mid-gastrocnemius, and lateral aspect of the foot of each leg for 3-D motion analysis. Footswitches (Myopac Jr., Run Technologies, Mission Viego, CA) were placed inside the subjects' shoes to determine timing of initial contact and the end of pre-swing in the gait cycle. Before overground and treadmill trials, individuals were asked to stand with feet shoulder width apart to collect neutral stance measurement. The Lumbosacral (L5/S1) joint, bilateral anterior superior iliac spine (ASIS), knee joints, ankle joints, and feet positions were captured during the neutral stance measurement. All kinematic variables were expressed with respect to this neutral stance or "zero" angle. Participants were instructed to walk across a 7.3 meter-long walkway at their self-selected walking pace for all overground conditions. The calculated overground velocity was then utilized to set the treadmill speed for both treadmill conditions. Participants practiced as needed to allow them to adapt to walking with the weight of the robot for both overground and treadmill conditions. Each participant wore a gait belt and was provided with standby assistance with one-minute seated rests between trials to minimize fatigue. All testing was conducted without subjects wearing any ankle foot orthosis.
where 0 ≤ SI ≤ 1 is the symmetry index and Vparetic and Vnonparetic are paretic and nonparetic percent stance durations, respectively. A lower value of the symmetry index indicates higher symmetry and vice versa with regards to stance durations on paretic and nonparetic sides. In other words, a symmetry index value of zero corresponds to perfect symmetry.
Repeated-measures analysis of variance (ANOVA) tests were conducted to test our hypothesis comparing OG vs. OGR and TM vs. TMR conditions using SAS® software (SAS, Cary, NC). The variables that were compared were paretic and nonparetic kinematics, step time and percent stance. Repeated-measures ANOVA tests were also employed to test the symmetry index. To compare across conditions (overground and treadmill) in a secondary analysis, we employed a post- hoc pair wise comparisons using Tukey's test. The significance level was set at p = 0.05 for all tests.
Physical and demographic characteristics of stroke participants.
Age (yr)/gender (M/F)
Range of Motion (°)
63(4M, 6F) a
a 6 L/4 R
a 2 AFOs, 4 canes
Spatiotemporal gait parameters
These findings support our hypothesis that asymmetric loading of the paretic limb would change bilateral joint kinematics in individuals with hemiparetic gait secondary to stroke. Specifically, the unpowered robot loading reduced nonparetic peak knee flexion on the TM and paretic peak dorsiflexion OG (p < 0.05). However surprisingly, mounting the anklebot on the paretic leg leads to no discernable differences in symmetry when walking overground or on the treadmill. It is important to emphasize that the entire study was conducted with the anklebot unpowered. When actively generating training torques at the ankle, these differences due to its added inertia and friction might get even smaller. As for our secondary analysis, similar to others , we found that walking on the treadmill showed greater symmetry than walking overground.
Previous work indicated that on average individuals with stroke walked overground at a faster preferred speed than on the treadmill . These results were unlike our findings since we sought to control for differences in speed to allow comparison across conditions. Therefore, the speed in TM and TMR conditions was set to match the OG velocity. The OGR velocity was not directly controlled; however, subjects still walked at a velocity similar to the other conditions.
For the individuals with stroke there were no major dissimilarities in bilateral step times and paretic stance among conditions. The variations in nonparetic stance durations were attributed to the overground and treadmill conditions as opposed to the added loading. The symmetry calculations showed that in the TM condition there was more symmetry between paretic and nonparetic stance phases compared to the OG condition. These findings were similar to previous studies that have shown greater symmetry when walking on a treadmill compared to over ground [3, 15, 17].
Our kinematic data also showed a 9°-10° increase in paretic maximum hip flexion on the treadmill regardless of loading condition. This difference may be attributable to an increased postural stability obtained due to holding the handrails on the treadmill. Also, there was a significant decrease in paretic maximum hip flexion in the OGR condition compared to both TM and TMR conditions. The ability to produce greater paretic hip flexion in the TMR versus OGR conditions indicates that the treadmill facilitated a greater hip range of motion. This underscores the fact that the added loading was not as influential as the treadmill in affecting these parameters. In contrast, nonparetic maximum knee flexion during the swing phase differed between the two treadmill conditions suggesting that this could have been due to the added robot loading. Furthermore, the robot loading significantly limited paretic ankle dorsiflexion during overground but not in the treadmill training. Our findings are distinct from prior studies where unilateral loading of healthy individuals showed major effect on ankle kinematics while they were walking on a treadmill [30–32]. These differences could be because on the treadmill, stroke volunteers benefited from greater postural support which may have caused the longer paretic side stance durations and altering loading responses observed at the paretic ankle. This could have been due to the repetitive nature of the treadmill task which may have potentially suppressed some of the features characteristic of impaired gait (e.g. circumduction).
Contrary to our findings, previous work has shown that unilateral loading of a limb during treadmill gait does not result in significant differences in hip or knee kinematics . This could be due to a lighter mass (approx. 1.7 kg) used to unilaterally load the limb in  which was less than half the mass of our ankle robot (approx. 3.6 kg). In addition, subject demographics could have also contributed to these differences, i.e., participants in  included three healthy males whereas all our participants were chronic stroke survivors. Overall, our results appear to suggest that walking on the treadmill with the leg unilaterally loaded or not has little impact on ankle kinematics. Furthermore, these kinematic deviations may be further reduced when the anklebot is used in active mode.
Of interest, not all subjects were able to ambulate with the added mass. Nine of the ten participants were able to ambulate with the added loading and those nine stroke survivors self-reported that they could wear the anklebot comfortably while walking overground and on the treadmill. One of the caveats of the study is that the small sample size is small; therefore, it was difficult to generate an accurate deficit profile for usage (i.e. to determine which individuals with hemiparesis can and cannot tolerate the weight of the ankle robot.)
In conclusion, the present data suggests that many individuals with hemiparesis can potentially wear an exoskeleton robot safely and with minimum disruption of their unloaded gait pattern.
List of abbreviations
analysis of variance
active range of motion
body mass index
mini mental state exam
Manual Muscle Testing
overground with the robot
passive range of motion
treadmill with the robot
University of Maryland
This work was supported by the Baltimore Veterans Affairs Medical Center "Center of Excellence on Task-Oriented Exercise and Robotics in Neurological Diseases" under Grant B3688R. VA Advanced Career Development Award under grant B3390K, VA Medical Center Baltimore Geriatrics Research, Education and Clinical Center (GRECC), University of Maryland School of Medicine, (NIA: Claude D. Pepper Older Americans Independence Act Center) Pepper Center grant P60AG12583.
- Heart Disease and Stroke Statistics- 2009 update, American Heart Association[http://www.americanheart.org/statistics]
- Knutsson E, Richards C: Different types of disturbed motor control in gait of hemiplegic patients. Brain 1979, 102: 405-430. 10.1093/brain/102.2.405View ArticlePubMedGoogle Scholar
- Chen G, Patten C, Kothari DH, Zajac FE: Gait deviations associated with post-stroke hemiparesis: improvement during treadmill walking using weight support, speed, support stiffness, and handrail hold. Gait Posture 2005, 22: 57-62. 10.1016/j.gaitpost.2004.06.008View ArticlePubMedGoogle Scholar
- Hsu AL, Tang PF, Jan MH: Analysis of impairments influencing gait velocity and asymmetry of hemiplegic patients after mild to moderate stroke. Arch Phys Med Rehabil 2003, 84: 1185-1193. 10.1016/S0003-9993(03)00030-3View ArticlePubMedGoogle Scholar
- Brandstater ME, de Bruin H, Gowland C, Clark BM: Hemiplegic gait: analysis of temporal variables. Arch Phys Med Rehabil 1983, 64: 583-587.PubMedGoogle Scholar
- Olney SJ, Griffin MP, McBride ID: Temporal, kinematic, and kinetic variables related to gait speed in subjects with hemiplegia: a regression approach. Phys Ther 1994, 74: 872-885.PubMedGoogle Scholar
- Olney SJ, Monga TN, Costigan PA: Mechanical energy of walking of stroke patients. Arch Phys Med Rehabil 1986, 67: 92-98. 10.1016/0003-9993(86)90109-7View ArticlePubMedGoogle Scholar
- Olney SJ, Richards C: Hemiparetic gait following stroke. Part I: Characteristics. Gait Posture 1996, 4: 136-148. [http://www.udel.edu/PT/rudolph/gaitJC/Olney-1996.pdf] 10.1016/0966-6362(96)01063-6View ArticleGoogle Scholar
- Chen G, Patten C, Kothari DH, Zajac FE: Gait differences between individuals with post-stroke hemiparesis and non-disabled controls at matched speeds. Gait Posture 2005, 22: 51-56. 10.1016/j.gaitpost.2004.06.009View ArticlePubMedGoogle Scholar
- Bensoussan L, Mesure S, Viton JM, Delarque A: Kinematic and Kinetic Asymmetries in Hemiplegic Patients' Gait Initiation Patterns. J Rehabil Med 2006, 38: 287-294. 10.1080/16501970600694859View ArticlePubMedGoogle Scholar
- Olney S, Richards C: Hemiparetic gait following stroke. Part II: Recovery and physical therapy. Gait Posture 1996,4(2):149-162. 10.1016/0966-6362(96)01064-8View ArticleGoogle Scholar
- Marigold DS, Eng JJ, Dawson AS, Inglis JT, Harris JE, Gylfadottir S: Exercise Leads to Faster Postural Reflexes, Improved Balance and Mobility, and Fewer Falls in Older Persons with Chronic Stroke. J Am Geriatr Soc 2005, 53: 416-423. 10.1111/j.1532-5415.2005.53158.xPubMed CentralView ArticlePubMedGoogle Scholar
- Hesse S, Bertelt C, Jahnke MT, Schaffrin A, Baake P, Malezic M, Mauritz KH: Treadmill training with partial body weight support compared with physiotherapy in nonambulatory hemiparetic patients. Stroke 1995, 26: 976-81.View ArticlePubMedGoogle Scholar
- Silver KH, Macko RF, Forrester LW, Goldberg AP, Smith GV: Effects of aerobic treadmill training on gait velocity, cadence, and gait symmetry in chronic hemiparetic stroke: a preliminary report. Neurorehabil Neural Repair 2000, 14: 65-71. 10.1177/154596830001400108View ArticlePubMedGoogle Scholar
- Harris-Love ML, Forrester LW, Macko RF, Silver KH, Smith GVS: Hemiparetic Gait Parameters in Overground Versus Treadmill Walking. Neurorehabil Neural Repair 2001,15(2):105-112. 10.1177/154596830101500204View ArticlePubMedGoogle Scholar
- Macko RF, Ivey FM, Forrester LW, Hanley D, Sorkin JD, Katzel LI, Silver KH, Goldberg AP: Treadmill Exercise Rehabilitation Improves Ambulatory Function and Cardiovascular Fitness in Patients With Chronic Stroke A Randomized, Controlled Trial. Stroke 2005, 36: 2206-2211. 10.1161/01.STR.0000181076.91805.89View ArticlePubMedGoogle Scholar
- Hesse S, Konrad M, Uhlenbrock D: Treadmill walking with partial body weight support versus floor walking in hemiparetic subjects. Arch Phys Med Rehabil 1999, 80: 421-427. 10.1016/S0003-9993(99)90279-4View ArticlePubMedGoogle Scholar
- Sullivan KJ, Knowlton BJ, Dobkin BH: Step Training With Body Weight Support: Effect of Treadmill Speed and Practice Paradigms on Poststroke Locomotor Recovery. Arch Phys Med Rehabil 2002, 83: 683-691. 10.1053/apmr.2002.32488View ArticlePubMedGoogle Scholar
- Mehrholz J, Werner C, Kugler J, Pohl M: Electromechanical-assisted training for walking after stroke. Cochrane Database Syst Rev 2007, 4: CD006185.PubMedGoogle Scholar
- Roy A, Krebs HI, Williams DJ, Bever CT, Forrester LW, Macko RM, Hogan N: Robot-Aided Neurorehabilitation: A Novel Robot For Ankle Rehabilitation. IEEE Transactions on Robotics 2009,25(3):569-582. [http://ieeexplore.ieee.org/xpl/freeabs_all.jsp?arnumber=4909072]View ArticleGoogle Scholar
- Blaya JA, Herr H: Adaptive Control of a Variable-Impedance Ankle-Foot Orthosis to Assist Drop-Foot Gait. IEEE Trans Neural Syst Rehabil Eng 2004, 12: 24-31. 10.1109/TNSRE.2003.823266View ArticlePubMedGoogle Scholar
- Noble JW, Prentice SD: Adaptation to unilateral change in lower limb mechanical properties during human walking. Exp Brain Res 2006,169(4):482-495. 10.1007/s00221-005-0162-3View ArticlePubMedGoogle Scholar
- Regnaux JP, Pradon D, Roche N, Robertson J, Bussel B, Dobkin B: Effects of loading the unaffected limb for one session of locomotor training on laboratory measures of gait in stroke. Clin Biomech (Bristol, Avon). 2008,23(6):762-768. 10.1016/j.clinbiomech.2008.01.011View ArticlePubMedGoogle Scholar
- Folstein MF, Folstein SE, McHugh PR: 'Mini-mental state'. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975, 12: 189-198. 10.1016/0022-3956(75)90026-6View ArticlePubMedGoogle Scholar
- Jones LA: Perceptual constancy and the perceived magnitude of muscle forces. Exp Brain Res 2003,151(12):197-203. 10.1007/s00221-003-1434-4View ArticlePubMedGoogle Scholar
- Kendall FP, McCreary EK, Provance PG, Rodgers MM, Romani WA: Muscles, Testing and Function With Posture and Pain. 5th edition. Baltimore: Williams & Wilkins; 2005.Google Scholar
- Bohannon RW, Smith MB: Interrater reliability of a modified Ashworth scale of muscle spasticity. Phys Ther 1987, 67: 206-207.PubMedGoogle Scholar
- Kendall FP, McCreary EK, Provance PG: Muscles: Testing and Function. 4th edition. Baltimore: Williams & Wilkins; 1993:270.Google Scholar
- Kim MC, Eng JJ: Symmetry in vertical ground reaction force is accompanied by symmetry in temporal but not distance variables of gait in persons with stroke. Gait Posture 2003, 18: 23-8. 10.1016/S0966-6362(02)00122-4View ArticlePubMedGoogle Scholar
- Ferris DP, Czerniecki JM, Hannafold B: An Ankle-Foot Orthosis Powered by Artificial Pneumatic Muscles. Journal of Applied Biomechanics 2005, 21: 189-197.PubMed CentralPubMedGoogle Scholar
- Gordon KE, Sawicki GS, Ferris DP: Mechanical performance of artificial pneumatic muscles to power an ankle-foot orthosis. Journal of Biomechanics 2006, 39: 1832-1841. 10.1016/j.jbiomech.2005.05.018View ArticlePubMedGoogle Scholar
- Wheeler JW, Krebs HI, Hogan N: An Ankle Robot for a Modular Gait Rehabilitation System. IEEE 2004, 2: 1680-1684. 10.1109/IROS.2004.1389637Google Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.