Figure 1
Representation, for each CMT1A patient, of changes of parameters associated to primary signs between the baseline (empty shapes) and the follow-up (arrow tips) evaluation. The threshold values of significance change for each parameter, 0.08 for AROMratio and 0.03 J/kg for AWst, are reported close to the correspondent axes. Double arrow = both parameters changed significantly, single arrow = only one parameter changed significantly, dashed arrow = no parameter changed significantly. Healthy controls are reported as filled circle. The horizontal and vertical red lines represent the 5th percentile values in the control subjects’ distribution of the two primary parameters associated, respectively, to foot-drop (AROMsw/AROMtot) and push-off deficit (AWst). Those values were used as threshold to define the inclusion in a given subgroup in the baseline evaluation: NL=normal-like (squares), FD=foot-drop (circles), FD&POD=foot-drop and push-off deficit (triangles). The subgroup of surgically operated patients is evidenced with a dotted ellipse.