Skip to main content
Figure 4 | Journal of NeuroEngineering and Rehabilitation

Figure 4

From: Mechanisms of human cerebellar dysmetria: experimental evidence and current conceptual bases

Figure 4

Wiring diagram of the cerebellar circuitry. Purkinje neurons are the sole output of the cerebellar cortex. Basket cells supply the inhibitory synapses via a synapse called "pinceau", stellate cells supply the inhibition to Purkinje cell dendrites. Lugaro cells are activated by serotoninergic fibers and inhibit Golgi cells. In addition to the illustrated serotoninergic afferences, cerebellar cortex receives other aminergic inputs (acetylcholine, dopamine, norepinephrine, histamine) or peptidergic projections (peptides such as neurotensin). These fibers project sparsely throughout the granular and molecular layers to contact directly the Purkinje neurons and other cerebellar neurons. Abbreviations: ST: serotoninergic fiber, pf: parallel fiber, Gran. c: granule cell, MF: mossy fiber, br. c: unipolar brush cell, CF: climbing fiber, IO: inferior olive, Gc: Golgi cell, Lc: Lugaro cell, Bc: basket cell, Sc: stellate cell, PN: Purkinje neuron; CN: cerebellar nucleus, mf: recurrent mossy fiber from nuclear cell.

Back to article page