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Table 3 Comparison of drug delivery micropump devices

From: An investigation into closed-loop treatment of neurological disorders based on sensing mitochondrial dysfunction

Title Mechanism Size (mm) Flow Rate (μl/min) Pressure (kPa) Frequency (kHz) Voltage (V)
A bidirectional silicon micropump [192] Electrostatic 7x7x2 850 0.31 2 200
A wireless implantable micropump for chronic drug infusion against cancer [194] Electrolysis 20x15x7.1 2.66 0.69 3
Design and test of a high-performance piezoelectric micropump for drug delivery [207] Piezoelectric 3.5 × 103 27 3 50
An Electromagnetically-Actuated All-PDMS Valveless Micropump for Drug Delivery [208] Electromagnetic 20x12x3.5 319.6 0.95 36.9 × 10− 3
A self-priming, roller-free, miniature, peristaltic pump operable with a single, reciprocating actuator [209] Peristaltic 8x22x35 780 48 3
A low cost, high performance insulin delivery system based on PZT actuation [210] Piezoelectric 22 × 18 × 6 4.34 × 103 14.64 0.2 36
An Ultrasonically Powered Micropump for On-Demand In-Situ Drug Delivery [211] Piezoelectric 22x7x5 13.8 4
Characteristic studies of the piezoelectrically actuated micropump with check valve [212] Piezoelectric 10x10x1 1.82 × 103 32 160 120
Design and simulation of a novel electrostatic peristaltic micromachined pump for drug delivery applications [193] Electrostatic 7x4x1 9.1 50 18.5
Piezoelectric micro-pump with PZT thin film for low consumption microfluidic devices [213] Piezoelectric 30 × 7.5 × 0.15 3.6 4 1 24
An Implantable MEMS Micropump System for Drug Delivery in Small Animals [195] Electrolysis 34 1.31 3
Piezoelectric Micropump with Nanoliter Per Minute Flow for Drug Delivery Systems [214] Piezoelectric 12x6x0.5 4.98 × 10−3 0.67 16
Design and simulation of an implantable medical drug delivery system using microelectromechanical systems technology [215] Peristaltic 70x35x1 100
A PMMA valveless micropump using electromagnetic actuation [216] Electromagnetic 400 1.2 12 × 10−3
A low voltage silicon micro-pump based on piezoelectric thin films [191] Piezoelectric 30 × 7.5 × 0.15 3.5 3.2 1 24
Study on a piezoelectric micropump for the controlled drug delivery system [217] Piezoelectric 52 0.4 140