Table 2 Experimental setup and description of tests in ISULA system

Finger chase test (FCT)

Kinect©

A Microsoft Kinect© V2, a 23 in. screen and a processing computer (Intel core i5) are installed approximately 1.5 m away the subject. The Kinect© captures movements from a 14 mm retro-reflective marker attached on the subject’s index finger. A program randomly generates the target point 20 times on the monitor while projecting the finger movement on the screen

The subject is required to point at and follow a target point on the screen using the index finger. As soon as the projected marker point touches the target point, the target disappears and reappears at a new position. The test is concluded after 20 iterations (Fig. 1a)

Finger tapping test (FTT)

IMU

A sensor was worn on the dorsum of the hand as depicted in Fig. 1(b)III

The subject is required to tap on a tabletop using the index finger at a self-selected and uniform pace. Tapping is performed for approximately 15 s with the elbow and shoulder joints unsupported to assess the stability of the platform (shoulder and elbow) (Fig. 1c)

Finger to nose test (FNT)

IMU

Similar to the setup of finger tapping test

The subject’s index finger moves repeatedly between the the clinician’s finger and the subject’s nose for approximately 15 s. The clinician’s finger is held stationary at a position approximately 50 cm in front of the subject (Fig. 1d)

Dysdiadochokinesia (DDKT)

IMU

A sensor was worn on the wrist as depicted in Fig. 1(b) II

The subject alternates between placing one hand palm-up and palm-down on the other hand as fast and precisely as possible for approximately 10 cycles (Fig. 1e)