Fig. 3
Relationship of types of Fluctuators to PTB and Clinical Scales. a. shows relative percentage (left Y axis) of Non Fluctuators-Controlled (NFC), Non Fluctuators-Uncontrolled (NFU) and Fluctuators (F) in each PTB category. The Severity Scores/Levels (right Y axis) for Early Morning Bradykinesia (EMB,
) and levodopa response (LR,
) are shown as box and whiskers plots. Short blue and green lines show the threshold for early morning bradykinesia or significant levodopa response (respectively). The percentage cases in each PTB category is shown at the top left corner of that category. b PTB plotted against Fluctuator Category. Blue boxes represent non-fluctuators (NFC and NFU) and pink boxes to the right show fluctuators (F) with the four subgroups of fluctuators (FCP: Controlled Fluctuator with persisting response; FCWO: Controlled Fluctuator with response that “wears off”; FUP: Uncontrolled Fluctuator with persisting response; FUWO: Uncontrolled Fluctuator with response that “wears off”). The p-values are from one-way ANOVA with Šídák’s multiple comparison test. Below each box the levodopa equivalent daily dose (median, upper line IQR, lower line in parenthesis) of each category are shown. Percentage in three left boxes shows the relative proportion of Non-Fluctuators and Fluctuators: percentage in right four boxes shows the relative proportion of the four fluctuator categories. c shows the bradykinesia Severity Score/Level (left Y axis) for early morning bradykinesia (EMB) and the LR of controlled non-fluctuators (NFC) and fluctuators (F) when PTD > 20% (other categories of fluctuators were too few to plot). Right of panel shows PTB and PTD scores (right Y axis) in NFC and F of cases with PTD > 20%. d and e UPDRS III and UPDRS Total plotted against Fluctuator Category with plots (X axis legend and p-values the same as panel (b)). Box plots show median and interquartile range and whiskers show 90th percentiles