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Table 4 Cross-tabulation of postinterventional effect sizes for studies evaluating non-invasive brain stimulation for improving gait, balance and/or lower limb recovery in stroke patients

From: Non-invasive brain stimulation for improving gait, balance, and lower limbs motor function in stroke

 

Stimulation induced effects on gait, balance and/or lower limb recovery (number of studies)

 

tDCS/tACS

rTMS

 

Small negative effect

No effect

Small positive effect

Medium positive effect

Large positive effect

Small negative effect

No effect

Small positive effect

Medium positive effect

Large positive effect

Overall

          
 

1

7

5

2

4

1

3

1

2

2

Stimulated hemisphere

        

Affected

1

5

2

 

1

    

1

Non-affected

 

1

  

1

1

2

1

 

1

Biateral

  

2

2

2

  

1

2

 

Centred

 

1

        

Spinal

  

1

       

Stimulated areas

        

M1

1

4

3

 

2

 

2

  

2

CR

 

2

   

1

 

1

  

M1 + M1

  

1

2

1

 

1

 

2

 

M1 + CR

    

1

     

SMA + M1

 

1

        

10Th

  

1

       

Stimulation protocol

        

1 Hz rTMS

     

1

2

  

1

5 Hz rTMS

         

1

10 Hz rTMS

        

1

 

20 Hz rTMS

        

1

 

iTBS

       

1

  

0.0–2.0 mA tACS

  

1

 

1

     

1.0 mA anodal tDCS

  

1

       

1.5 mA anodal tDCS

1

2

        

2.0 mA anodal tDCS

 

4

1

 

1

     

1.0 mA anodal + cathodal tDCS

 

1

        

1.5 mA anodal + cathodal tDCS

          

2.0 mA anodal + cathodal tDCS

  

1

1

1

     

2.0 mA cathodal tDCS

    

1

     

2.5 mA cathodal tsDCS

  

1

       

Stimulation duration

        

 ≥ 99 min

1

3

2

1

 

1

2

 

1

 

100–199 min

 

3

  

1

 

1

1

 

2

200–299 min

 

1

2

 

3

     

 ≤ 300 min

  

1

1

    

1

 

Time since stroke

        

0.1–3.2 months

 

2

2

1

3

1

1

   

11.0–29.0 months

1

 

0

   

2

1

2

2

42.0–120.0 months

 

5

3

1

1

     
  1. No effect (d < 0.2), small effect (d = 0.2–0.49), medium effect (d = 0.5–0.79), large effect (d ≥ 0.8), CR   cerebellum, Hz   hertz, iTBS   intermittent theta burst stimulation, mA   milliampere, M1   primary motor cortex, rTMS   repetitive transcranial magnetic stimulation, SMA   supplementary motor area, tACS   transcranial alternating current stimulation, tDCS   transcranial direct current stimulation, tsDCS   trans-spinal direct current stimulation, 10Th   the tenth thoracic vertebra