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Table 2 Study characteristics for all 18 quasi-experimental studies

From: Effect of mobile application types on stroke rehabilitation: a systematic review

Author, year

Study design

Intervention

Intervention description

Outcome

Result summary

Ballard et al., 2019

Pretest posttest design

Therapy app

Word Trainer: iOS app using ASR to support near-independent practice in word production

Adherence, aphasia scores

No substantial adherence from baseline was shown. However, all participants showed improved word production accuracy and maintenance of gains through the study

Kerry et al., 2019

Pretest posttest design

Therapy app

iReadMore: app aimed to retrain whole-word reading by showing users pictures associated with written and spoken words

Aphasia scores

Using iReadMore increased word-reading accuracy for trained words compared to untrained words

Pugliese et al., 2019

Pretest posttest design

Therapy app

RecoverNow tablet: device preset with specific therapeutic apps for stroke-induced deficits

Adherence

Adherence to intervention was shown to be poor in this study. Barriers to intervention use were categorized as device, patient, and system. App difficulty was the most frequently encountered barrier

Requena et al., 2019

Nonrandomized clinical trial

Reminders

Farmalarm: Android app with visual and audible alerts to increase stroke awareness and treatment adherence

Secondary prevention

The intervention group had more vascular risk factors under control, higher rate of overall vascular risk factors controlled, and higher rate of patients with controlled diabetes mellitus and hypercholesterolemia

Kamwesiga et al., 2018

Nonrandomized clinical trial

Reminders

F@ce intervention: 2 SMS messages per day sent to users to work on three pre-set ADL targets

ADLs

F@ce intervention had no effect on ADLs compared to the control group

Kurland et al., 2018 and 2014

Pretest posttest design (2014 was a pilot test)

Therapy app

HP iBooks: app with series of semantic, phonemic, and orthographic cueing in pictures, words, and videos to help with naming prior pictures

Aphasia scores

Both the 2014 pilot trial and 2017 study suggest that a tablet-based HP programs support maintenance of post-treatment language gains and naming of pictures in individuals with chronic post-stroke aphasia over short and long-term use

Sarfo et al., 2018

Pretest posttest design

Rehab videos

9zest Stroke Rehab App: delivers individualized, goal-targeted 5 days/week video exercise programs

Motor paresis, adherence, ADLs

Higher scores on the Stroke Levity Scale, modified Rankin score, and Barthel’s index score indicates improved motor paresis and less dependence for ADLs. Increased adherence was found in users whose MoCA scores increased with 9zest

Stark et al., 2018

Crossover design

Therapy app

Language Therapy: task based app focused on reading, naming, writing, and comprehension

Bejeweled: a spatial awareness and decision mind-game app

Aphasia scores

Aphasia measures via the Comprehensive Aphasia Test and Cookie Theft Picture Description were improved after using the Language Therapy app but not Bejeweled in patients with chronic post-stroke expressive aphasia

Hald et al., 2017

Pretest posttest design

Therapy app

WAM: moles appear on app screen for users to tap with negative or positive feedback

Neglect scores

Negative feedback via WAM resulted in faster reaction times whereas positive feedback led to slower reaction times in stroke patients with hemi-spatial neglect

Lawson et al., 2017

Pretest posttest design

Therapy app

ARMStrokes: app with 8 upper extremity exercises using phone sensors

Motor paresis, ADLs

Increased upper extremity function (PROM, AROM, coordination) and improved ability to perform ADLs

Choi et al., 2016

Pretest posttest design

Therapy app

iAphasia: app with voice-guided tasks based on 6 aphasia therapeutic domains

Aphasia scores

Mean K-WAB scores improved from baseline values, with auditory comprehension, reading, name, and fluency seeing the most benefit

Kizony et al., 2016

Experiment II only

Pretest posttest design

Therapy app

iPad Apps: combined multiple apps (ScribbleKid PegLight, Tap-it, Bowling game) for hand rehab

Motor paresis

Practice effect leading to better performance was more apparent in users with more hand dexterity at baseline

Paul et al., 2016

Nonrandomized clinical trial

Reminders

STARFISH: self and group monitoring app which acts to remind users to do physical activity

Adherence, motor paresis, ADLs, quality of life, secondary prevention, depression/anxiety

Use of STARFISH increased adherence to physical activity but otherwise had no impact on motor function, ADLs, quality of life, secondary prevention, and depression/anxiety

Sureshkumar et al., 2016

Pretest posttest design

Education app

Care for Stroke: delivers information about stroke and post stroke disability management on an app

ADLs

This study showed improvement in ADL markers (Barthel Index and modified Rankin Scale) between before and after the intervention period

Seo et al., 2015

Pretest posttest design

Reminders

KUHMS2: app where users record daily values for vascular risk factors, with alarms messages if values were beyond the normal parameters

Secondary prevention

Regarding secondary prevention, the app improved BP and HbA1c values whereas some positive trends were found for waist circumference and smoking cessation

Carabeo et al., 2014

Pretest posttest design

Therapy app

FINDEX: game app focused on fine motor skills via everyday activities

Motor paresis

Fine finger dexterity in the last testing session generally improved compared to the initial measuring session

Hoover et al., 2014

Pretest posttest design

Therapy apps

iPad in ICAP–iPad and a variety of apps were used to enhance therapies (PT, OT, CILT),

Quality of life

SIS and ASHA FACS scores were significantly improved from pre to post treatment period, indicating an increased quality of life through an iPad in ICAP

  1. ADL,  activities of daily living; PROM,  passive range of movement; AROM,  active range of movement; K-WAB,  Korean version of the Western Aphasia Battery; ASR,  automatic speech recognition; WAM,  wack-a-mole; SMS,  short message service; MoCA,  Montreal Cognitive Assessment; HP,  home-practice; KUHMS2,  Korea University Health Monitoring System for Stroke; BP,  blood pressure; ICAP,  intensive, comprehensive aphasia program; PT,  physiotherapy; OT,  occupational therapy; CILT,  constraint induced language treatment; SIS,  stroke impact scale; ASHA FACS,  American Speech-Language-hearing Association Functional Assessment of Communication Skills for Adults