Effect of exoskeleton-assisted Body Weight-Supported Treadmill Training on gait function for patients with chronic stroke: a scoping review

Background Therapeutic exercise for gait function using an exoskeleton-assisted Body Weight Supported Treadmill Training (BWSTT) has been identified as a potential intervention that allows for task-based repetitive training with appropriate kinematics while adjusting the amount of body weight support (BWS). Nonetheless, its effect on gait in patients with stroke in the chronic phase are yet to be clarified. The primary aim of this scoping review was to present the status of effectiveness of exoskeleton-assisted BWSTT in patients with chronic stroke. The secondary aims were to summarise intervention protocols, types and functions of BWSTT exoskeletal robotic devices currently used clinically. Method and results Articles were accessed and collected from PubMed, Ovid MEDLINE, Cochrane Central Register of Controlled Trials, and Web of Science databases, which were completed in October 2020. Articles were included if the subjects were adults with stroke in the chronic phase (onset ≥ 6 months) and if they utilised a robotic exoskeleton with treadmill and body weight support and investigated the efficacy of gait exercise. A total of 721 studies were identified, of which 11 randomised controlled trials were selected. All included studies were published from 2008 to 2020. Overall, 309 subjects were enrolled; of these, 241 (156 males, 85 females) participated. Walking outcome measures were used more often to evaluate the functional aspects of gait than to evaluate gait independence. In 10 of 11 studies, showed the effectiveness of exoskeleton robot-assisted BWSTT in terms of outcomes contributing to improved gait function. Two studies reported that exoskeleton-assisted BWSTT with combination therapy was significantly more effective in improving than exoskeleton-assisted BWSTT alone. However, no significant difference was identified between the groups; compared with therapist-assisted BWSTT groups, exoskeleton-assisted BWSTT groups did not exhibit significant change. Conclusion This review suggests that exoskeleton-assisted BWSTT for patients with chronic stroke may be effective in improving walking function. However, the potential may be “to assist” and not because of using the robot. Further studies are required to verify its efficacy and strengthen evidence on intervention protocols.

after intensive rehabilitation, 30-40% of these patients still have limited ability to walk [2][3][4]. Exoskeletonassisted Body Weight Supported Treadmill Training (BWSTT) has gained attention over the past few decades as a popular method of post-stroke gait training due to its advantages for task-based repetitive training [5][6][7][8][9][10]. However, for patients with stroke in the chronic phase, improvements in gait, its outcome measures and specific intervention protocols have yet to be clarified.

Chronic stroke
In this review, we defined chronic phase in stroke as equal to or more than 6 months after stroke onset. It has been suggested that the majority of functional recovery after stroke onset occurs in the acute phase and plateaus from 3 to 6 months after onset. However, previous studies have shown that specialised and intensive training can improve motor function in patients with chronic stroke who have motor dysfunction [11][12][13][14]. Moreover, the degree and amount of improvement in motor function has been reported to be correlated with the intensity and frequency of rehabilitation [15][16][17].

Robotic devices in gait rehabilitation
A search in the PubMed for articles related to gaitassist robots used in rehabilitation yielded no results prior to 1989, although the number of articles rapidly increased from 2003 to 2020 as the field was recognised in rehabilitation. The application of robotic technology to rehabilitation has substantially increased in recent years [18][19][20][21][22] and several gait-assistive robotic devices are already available on the market [5-10, 23, 24]. The available assistive robot systems include HAL (CYBERDYNE Inc., Japan), Welwalk (Toyota Motor Corporation, Japan), Lokomat (Hocoma AG, Switzerland), Ekso (Ekso Bionics, USA), and many others are currently undergoing development. All these devices possess one or more of the following functions: a bodyweight-support device, a treadmill, or an overground walking system. The devices used for gait exercises utilise electromechanically actuated motors that control movement and exert force on the joints or parts of the lower limbs. These are categorised as exoskeleton type, end-effector type and other [25] (Table 1, Fig. 1a, b). The exoskeleton type is wearable and assists the patient by applying output torque directly at the targeted lower limb joints during gait training. The timing and intensity of the assistance is programmed and given during the entire gait cycle or in a specific phase. The endeffector type is a device placed on the plantar that provides assistance of the ideal gait trajectory to the foot (peripheral). Types stated as other included powered walking frames, powered ankle foot orthosis or nonexoskeleton wire-driven types. Unlike end-effector type robots, which have a fixed end and input programmed motion trajectory, exoskeletons are intended to compensate for lost gait function, characterised by dynamic assistance or control of the rotational motion of the target joints. In equipment associated with exoskeletons (Fig. 1b), the adjustable body weight support (BWS) function, which prevents falls, may safely accommodate patients with a wide range of gait function levels from Functional Ambulation Categories (FAC) 0-4 [26]. The treadmill also facilitates speed adjustment and repetitive gait input in a set position. BWSTT has been reported to significantly improve balance, gait speed, and endurance in stroke patients [27,28]. Furthermore, it has been reported that gait training with adjusted weight bearing instead of full weight improves walking speed and endurance on level ground, leading to improved gait [29,30]. BWSTT is highly effective in improving gait in patients who have suffered subacute stroke, but its effectiveness is not clear in chronic stroke [27,29,31]. It has been reported that gait-assistive robot training has an impact on gait improvement [27]. On the other hand, literature comparing the effects in terms of differences by type of gaitassist robot and stage of the target patients is limited, and effects on specific endpoints are not yet clear [25,32,33]. Moreover, results may differ depending on the clinical trial design and intervention protocols.

Gait exercise for stroke
Currently, several forms of intervention in gait training have been proposed for the management of stroke. Conventional physiotherapy for walking after stroke generally includes muscle strengthening, functional task practise, symmetrical movement practise (including weight bearing and shifting training), stepping and single-leg standing targets for practising specific gait phases, circuit training, and neurodevelopmental techniques [34]. Most conventional gait retraining is undertaken with hands-on assistance, which is potentially physically taxing for the therapist. Frequent intense gait training interventions have been shown to result in higher overall functional improvements in patients with stroke in chronic phase [5][6][7][8][9][10]. However, the physical burden and time/cost required to maintain such functions are a key challenge amongst therapists, as well as patients in the chronic phase after stroke.
The use of technology-enhanced gait training for rehabilitation which gives mechanically assisted task-based repetitive training is expanding; nonetheless, its competence is still being argued. A previous study reported that individuals who received electromechanical-assisted gait training in combination with physiotherapy after stroke were more likely to achieve independent walking than people who received gait training without these devices [25,31]. In another study, therapist-assisted locomotor training was superior to robotic-assisted locomotor training amongst ambulatory survivors with chronic stroke [35]. In addition to refining the application of devices and determining patients who may benefit from robot-assisted training, the identification of an effective combination therapy crossover is essential.
In summary, although significant research has been done on exoskeleton robotic rehabilitation, only minimal research has been conducted on its application in patients with chronic stroke. Moreover, investigations on the efficacy of devices used in robotic gait exercise in the chronic phase are limited, and the current situation is unclear. At the same time, while various types of robotic assistive devices have been developed to date, the trends in equipment, design, and functional requirements specifically for the chronic phase are still not well known [27,29,31].
Therefore, this study aimed to review and describe the effectiveness of exoskeleton assisted BWSTT in patients with chronic stroke. And the second objectives were to summarise intervention protocols and the types and functions of BWSTT exoskeletal robotic devices currently used clinically.

Methods
The literature review protocol was developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement [46], and with reference to the work conducted by Arksey and O'Malley [47], Ferrari [48] and Peters [49].
Articles were accessed and collected from PubMed, Ovid MEDLINE, Cochrane Central Register of Controlled Trials, and Web of Science databases, which were completed on October 27, 2020.
The primary search was conducted using combined terms: (robot* OR exoskeleton OR "powered gait orthosis" OR PGO OR HAL OR "hybrid assistive limb" OR ReWalk OR Ekso OR Indego OR lower-extremity robot OR robotic-assisted OR electromechanical OR mechanically assisted OR powered assisted OR robotic device OR Welwalk OR electromechanical-assisted OR robotic OR end-effector OR assist robot OR GEAR OR robotic orthosis OR rehabilitation robotics OR orthotic devices OR Lokomat) AND (stroke OR poststroke OR CVA OR "cerebrovascular accident" OR "cerebral infarct" OR "cerebral haemorrhage" OR hemiplegia OR hemiparesis) AND (gait OR walk OR walking OR ambulation OR gait training) AND (chronic OR community OR at home). Additionally, the following parameters were used: clinical trial/ RCT and scientific articles written in English, with its full text available to all the authors. Date was not restricted. Additional references were also identified by manual search, and duplicates were removed.
The inclusion criteria were as follows: • Interventions, allocated subject group, and outcome measures that refer to the efficacy and/or effectiveness of gait exercise and exoskeleton-assisted BWSTT • Human subjects: post-stroke, hemiplegia in the chronic phase with onset at ≥ 6 months The selection process is shown in the flow diagram in Fig. 2 [46].
With respect to the reference selection process and the inclusion and exclusion criteria above, the titles and abstracts of potential articles were screened by two reviewers to remove irrelevant studies. Potentially     eligible studies were chosen from the remainder if full texts were available. From the final selected studies, data on the study design and subjects, equipment used for the interventions, gait exercise treatment protocol, evaluation tools, and reporting of information on the effectiveness of clinical gait exercise were extracted from the selected articles to provide information on the results and effects that would be useful in clinical practise (Table 2). Additionally, data on the characteristics, type and functional requirements of the gait assistive robots as devices used in the selected literature were summarised to analyse them for use in the chronic stage (Table 3).

Results
The PRISMA flow diagram for this study is presented in Fig. 2. Overall, 721 studies were identified through database search, and 48 additional potentially relevant studies were found through manual search. From a total of 769 studies, 350 were retrieved by screening the studies' written language and article type. Additionally, duplicate records were removed. After assessing the eligibility of articles based on the title, abstract, and full text, 11 were selected. All included studies were published from 2008 to 2020. Six studies were published between 2015 and 2020 and five studies were published before 2014.

Study design
All included studies were RCTs or randomised crossover trials. Most studies included fewer than 30 participants and were recognised as small-scale pilot studies except for three RCTs [35,44,45] which included 34, 48, and 48 participants.

Participants
A total of 309 subjects were enrolled in all included studies; of these, 241 (156 males, 85 females) participated. All participants were patients with chronic stroke with onset at ≥ 6 months. The mean age was 57.8 ± 7.0 years. The subjects were community residents or recruited from the outpatient department in three studies [42,43,45], were hospitalised in four studies [36,37,41,44], and belonged to other categories or were unknown in four studies [35,[38][39][40].
In addition, in a few studies, the subjects were conditioned to a certain level of walking prior to the intervention (a level of independence in which the subjects were able to walk for more than 10 m without a walking assistive device or without receiving walking assistance). Few studies also involved the use of a cane, orthotic device, or walker to walk for more than 10 m.

Training period
The duration of intervention and the duration of a session differed in each study. In the included studies, the duration of intervention ranged from 3 weeks [45] to 5 months [36], and the number of training sessions varied from nine [45] to 12 sessions [35,[38][39][40], 18 sessions [44], and 20 sessions [36,41,42].
The duration of one session of lower-limb robotic gait training was 30 min [38,39,41,44,45], 45 min [37], and 60 min [36,42,43], with 30 min being set in approximately half of the studies. In addition, the frequency range was, in descending order of days, five days a week [43,43], three days a week [38-41, 44, 45], and two days a week [41]. Most of the studies were conducted five or three times a week.

Training protocol and subject group characteristics
All selected studies utilised gait training on a treadmill and included BWSTT robot-assisted gait training as the intervention. The characteristics of the training protocol and comparison groups were as follows: the most frequent comparisons were robot-assisted gait training groups vs. therapist-assisted groups [35,36,38,39], and the second most frequent comparisons were robotassisted gait training with combination therapy groups vs. robot-assisted gait training groups. Combination therapy was described as transcranial direct current stimulation (tDCS) [40] or functional electrical stimulation (FES) [41]. Robot-assisted gait training with conventional therapy was compared with robot-assisted gait training alone in one study [45], the effects of robot-assisted gait training were compared between the affected and nonaffected sides in another study [37], and the intervention was evaluated in BWSTT robot-assisted gait training groups vs. a robot-free group in two studies [42,43].
Additional studies compared an exercise loading index, heart rate reserve, and rating of perceived exertion for robot-assisted gait training [44] and compared the effects of different walking speeds between robot-assisted groups [54].

Outcome measures
Walking outcome measures were used more often to evaluate the functional aspects of gait than to evaluate gait independence. Two studies evaluated the Functional Ambulation Category [37,40] and Rivermead Visual Gait Assessment [45] as the measures of gait and mobility independence. Two studies either measured the walking speed or utilised the 10-m walk test as a quantitative assessment of gait function [40,44]. In addition, two studies [35,43] assessed gait endurance using the 6-min walk test, whereas four studies [36,39,40,43] assessed it using the Timed Up and Go Test. Four studies [36,[40][41][42] assessed balance ability using the BBS. Three studies evaluated spatiotemporal parameters such as stance time and stride length, floor reaction force data, and kinematic gait parameters such as angular changes in each joint were measured using a 3D motion capture system [38,42,44]. Except for those mentioned above, with respect to performance-based outcome measures that are directly related to gait assessment, the Modified Ashworth Scale  [45] was investigated as a score of spasticity and a scale of sensorimotor function in stroke. In another study using combination therapy, robot-assisted gait training was undertaken with neurophysiological assessment using an electroencephalogram (EEG). Furthermore, four of the 11 studies included self-reported assessments for depression and satisfaction with treatment (Hamilton Rating Scale for Depression, Center for Epidemiological Studies-Depression Scale [35,36], Global Rating of Change [42]).

Types of exoskeletons and their control methods
In all selected studies, exoskeletons utilised a combination of a treadmill and BWS system. In this review, the most utilised exoskeleton was Lokomat, which was used in seven studies [35,36,[38][39][40][41]44]. The Wellwalk prototype was used in two studies. [42,43]. Other exoskeletons used were Walkbot [37] and RoboGait [45]. Wellwalk was the only unilateral type; the other exoskeletons had a bilateral set-up. Lower-limb robots utilised the following joint assistance: Walkbot: hip knee and ankle tri-joint control [37]; Lokomat and RoboGait: hip and knee bi-joint control [35]; and Gait Exercise Assist Robot (GEAR) system/ Wellwalk: knee and ankle joint bi-joint control [42,43]. These four lower-limb robotic devices have an integrated BWS system and treadmill. Of these, Lokomat [35,36,[38][39][40][41]44], Walkbot [37], and RoboGait [45] have a pelvic immobilisation device in addition to the assisted joint to fix the trajectory of the centre-of-gravity movement in the pelvis. In the GEAR system/Welwalk [42,43], the pelvic movement is not fixed and is relatively free. All the above-mentioned devices are equipped with visual and auditory feedback functions and the ability to see the patient's gait. Table 3 provides further details about all four devices, including their design and type of actuator, and describes these devices, including control strategies and their function.

Walking speed and BWS in treadmill gait training
The setting criteria for the treadmill walking speed varied. Some studies did not state a numerical speed but specified it as the maximum speed that the patients could achieve [42,43]. Alternatively, some studies used an individual patient's comfortable speed that decreased to the appropriate speed [40] or set a constant speed (2.5 km/h to 3.0 km/h [39], 0.2 km/h to 3.2 km/h [45]). In addition, some had a fixed starting speed, with gradual increases in speed in accordance with the patients' maximal effort and improvement (starting at 0.8 km/h to 1.5 km/h [36] or 1.2 km/h [41,44]). Others had a fixed maximum speed, and the speed gradually increased within the upper limit of its maximum value (up to 2.2 km/h [37] and up to 3.0 km/h [35,38]).
The criteria for BWS also varied widely. In some studies, BWS at the beginning of the protocol was set as the percentage of each patient's body weight and was gradually decreased based on the patient's ability or improvement [36,38,40,41,44]. In particular, most studies were based on a gradual decrease in the upper limit of BWS from 40% [38,40,41,44] and from 50% [36] at the start of the protocol. The lower limit was set in the range of 0-20%, depending on the patient's improvement and change in ability [36,40,41,44].

Efficacy of BWSTT exoskeleton-assisted gait training and results of individual studies
In all 11 RCTs, the effects of exoskeletal robot-assisted training varied due to different intervention protocols, intervention periods, and lower-limb robotic devices used ( Table 2). The results were classified according to the characteristics of the subject groups as follows: Four studies [35,36,38,39] were categorised into BWSTT-robot assisted gait training (BWSTT-RAGT) vs BWSTT-therapist assisted gait training (BWSTT-TAGT) ( Table 4, 4.1). In all three studies [35,36,39], both groups showed improvement in gait outcome measures (Table 4) when comparing within each group. However, no significant between-group difference was observed [35,36,39]. In one study [35], the BWSTT-RAGT group had a lower improvement in walking speed (self-selected velocity and fast velocity) than the BWSTT-TAGT group. In addition, the results of one study [38] indicated that robot-assisted gait training groups did not show a significant change within and between groups.
In BWSTT-RAGT vs BWSTT-RAGT with combination therapy (Table 4, 4.2), two studies [40,41] reported that robot-assisted BWSTT-RAGT with combination therapy was significantly more effective in improving gait mainly in activity level of outcome within and between groups than BWSTT-RAGT alone. Furthermore, in a study using tDCS as combination therapy [40], the BWSTT-RAGT with active tDCS group showed greater improvements in 10 MWT (10 Metre Walk Test), FAC, and SIS-16 (Stroke Impact Scale-16) measures except for the BBS than the sham group. In another trial investigating the effects of an intervention combining robot-assisted gait training and FES, maximal knee flexion during gait was significantly greater than that before training in the BWSTT-RAGT with FES group [41].   [42,43]. In these two studies, effects were found within the BWSTT-RAGT group for activity level measures, including the 10MWT. There were no significant differences between the groups regarding kinetics and gait pattern changes [42]. However, quantitative measures of gait, such as TUG and 6-min walk, in the BWSTT-RAGT were higher than in the BWSTT group [43].
In other categories summarised in Table 4, 4.4, one study [45] which compared with conventional physiotherapy showed greater improvement in gait function between group in BSWTT-RAGT group. One of the studies compared the effect of robot assistance on the unaffected limb or affected limb during BWSTT-RAGT [37], and others compared the method of guiding the target of BWSTT-RAGT [38]. Both studies [37,44] showed significant improvement in outcome measures both in body function/structure and activity level in both conducted BWSTT-RAGT groups.

Discussion
The purpose of this review was to present and assess the status of effectiveness of robot-assisted BWSTT. Eleven studies were included, indicating that only a small number of RCTs on this topic have been published. As the date of publishing ranged from 2008 to 2020, it could be said that this is a relatively new field. Additionally, more positive improvements in walking in the acute to subacute phase have been reported [26,31,57]. There exist Each study was categorised according to the characteristics of the comparison group under investigation. The results of BWSTT-RAGT intervention groups in pre-post change (p < 0.05) and results compared to the control group are shown. Descriptive values are presented as the mean change and d describes effect size. Results were categorised as Body function/structure level and Activity level [55,56].  few reviews about BWSTT robot-assisted gait exercise that focus on the chronic phase after stroke; hence, its efficacy remains unclarified.

Effect of robot-assisted gait training in the chronic phase after stroke
There is an expectation that robotic rehabilitation will lead to a paradigm shift in work due to the therapeutic effect on the patient and the reduced burden on the therapist. From this perspective, the results of this review lead to the conclusion that it is not possible to conclude that BWSTT-RAGT is significantly more effective.
We have identified from the study protocol that it is relevant to address papers that present the results of the target intervention group which investigate the effect of exoskeleton used RAGT from the perspective of scoping the current RAGT.
The four of the 11 selected studies compared BWSTT-RAGT with BWSTT-TAGT, indicated that there was either no significant difference between the groups [36,38,39] or a predominant change in the therapist-assisted group as compared to that in the group receiving conventional gait exercise and the group receiving robot-assisted gait exercise [35]. Therefore, we did not reach the conclusion that the robot was more effective than the therapist for chronic stroke patients.
On other hand, those comparing the BWSTT-RAGT only group to the BWSTT-RAGT with combination therapy group (tDCS [40], FES [41]) have reported significant effects on improving gait outcome measures in between groups. Further research is encouraged, as BWSTT-RAGT with combination therapy may further enhance the efficacy of BWSTT-RAGT. Furthermore, there are studies excluded from the conditions for acceptance, although the following studies have been reported. In studies reporting on improvements in brain function levels that may be involved in the improvement of gait function and an RCT focusing on robot assisted gait training with combination therapy using visual stimulation with VR had shown and identified three main areas of brain activity, as measured by electroencephalography that were significantly evident in the robot assist with VR group [58]. Another RCT [59] of BSWTT-RAGT reported improvements in cognitive flexibility and shifting skills, selective attention/visual research, and quality of life.
The results of two out of 11 references [42,43], which were from the same research group, and BWSTT-RAGT was effective between the groups, depending on the outcome. These indicate that BWSTT-RAGT in addition to BWSTT alone may be more effective than BWSTT alone in improving dynamic balance, speed and endurance during gait [43], but the actual changes in gait pattern in kinetics are not yet cleared [44]. Additionally, in a comparison of BSWTT-RAGT and Conventional Physiotherapy [45], the BSWTT-RAGT group showed a significant improvement between groups.
To summarise these results, some showed that BWSTT-RAGT was more effective than the target group, while others showed no significance. These results indicate that BWSTT-RAGT seems to be more effective than gait training with BWSTT alone, whether the robot or the therapist provides the assistance. Regarding gait assistance, it is unclear whether it is worthwhile to use the current exoskeletal robot. Nevertheless, from the viewpoint of dependency of neural plasticity and training dose, it is impractical for therapists to provide longterm assistance in gait rehabilitation, therefore the use of robots should be advantageous from a clinical point of view. In addition, the significance of combination therapy together with BWSTT-RAGT has been demonstrated to be more effective than conventional physiotherapy, indicating that exoskeleton robot-assisted training has potential, with further research expected in the future.

Types of exoskeleton design
Amongst the selected studies, there were four BWSTT-type exoskeletal robots: Lokomat, Walkbot, RoboGait, and GEAR system. The GEAR system is a prototype of the Welwalk and is already in clinical use as of 2021. The features of the devices and the details of assistance methods and intervention protocols vary. The differences in gait exercise effects between them are also not yet clear [60].
Lokomat and Walkbot are characterised by restricted motion of the pelvic girdle in the sagittal plane. The pelvic girdle's semi-fixation in a certain position may reduce the abnormal gait pattern of the lower-limb joints [61]. With Lokomat, the timing of each muscle's activation during gait is changed by adjusting the speed and guidance force [61]. On the other hand, with Welwalk, the pelvis is not fixed by the device, and there is more freedom in the direction of movement as compared to that with Lokomat and Walkbot. Other than the feature of BWS on the treadmill, the Welwalk can be used in situations closer to overground walking.
Regarding the protocol for adjusting the assist, there are a wide variety of possible assist trajectories, assist volumes, torque values at the joint, and control strategies. All included studies employed assist-asneeded approaches tailored to the gait of individual patients [35][36][37][38][39][40][41][42][43][44][45]. In all studies reviewed, these settings were applied and adapted to the subjects' gait using an exploratory and experimental approach. For comparisons of effectiveness, the details of the settings of these elements need to be considered.

Summary of future research questions
Based on the results of this review, future research questions and directions are discussed. Firstly, are there purpose-specific combinations of exoskeletonassisted BWSTT and effective combination therapies for use in patients with chronic hemiplegia? If there are, what are these purpose-specific combinations? Secondly, do the effects of various robotic devices on gait training differ among patients with chronic hemiplegia? Currently, the clinical use of exoskeleton-assisted BWSTT in patients with chronic stroke remains unclear due to a lack of evidence. Large RCTs in which patient recruitment, numerical assisted adjustments, treadmill speed, and details of intervention protocols that are compared with a control group will be needed in the future. This may aid in determining the appropriate applications of exoskeleton-assisted BWSTT.

Limitations
The quality of evidence has not been assessed in the literature. A greater range of intervention methodologies and non-specific selection of case types need to be included. The type and severity of subjects' disability, as well as intervention methodologies and protocols, are not considered and included. To address these limitations in the future, a high-quality systematic review with an expanded scope is necessary to be conducted.

Conclusions
This review suggests that exoskeletal robot-assisted BWSTT for patients with chronic stroke may be effective in improving walking function as 10 out of 11 studies showed the effectiveness of exoskeleton robotassisted BWSTT in terms of outcomes contributing to improved gait function. However, the potential may be "to assist" and not because of using the robot. In other words, the effect could be attributed to assisting, irrespective of whether it is due to a robot or therapist.
Further studies are required to verify the effectiveness of BWSTT exoskeletal robotic training in patients with chronic stroke, strengthen the evidence on intervention protocols, and provide detailed information regarding the application of different robot types to enable best practise for the benefit of patients.