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Table 4 Main findings in meta-analyses

From: Virtual reality-based therapy improves balance and reduces fear of falling in patients with multiple sclerosis. a systematic review and meta-analysis of randomized controlled trials

 

Summary of findings

Grade quality evidence

Effect size heter

Publication bias

K

N

Ns

SMD

95% CI

I2 (p-value)

funnel plot (Egger p-value)

trim and fill

Risk of bias

Incons

Indirect

Imprec

Publication bias

Quality evidence

Adj SMD

% var (%)

Functional balance

16

451

28.1

0.8

0.47 to 1.14

0% (p = 0.47)

Slightly Asym (p = 0.89)

0.94

16

Medium

No

No

Yes

Probable

Moderate

Dynamic balance

16

494

30.8

− 0.3

− 0.48 to − 0.11

3.7% (p = 0.48)

Asym (p = 0.24)

− 0.18

42

Medium

No

No

Yes

Yes

Low

Sway area EC

3

81

27

− 0.54

− 0.99 to − 0.1

0% (p = 0.55)

Slightly Asym (p = 0.27)

− 0.54

0

Medium

No

No

Yes

No

Very-low

Centre of pressure escursion EO

8

189

23.6

− 0.25

− 0.5 to − 0.01

0% (p = 0.99)

Asym (p = 0.48)

− 0.26

8

Medium

No

No

Yes

Probable

Low

Confidence of balance

4

176

44

0.43

0.15 to 0.71

0% (p = 0.93)

Slightly Asym (p = 0.51)

0.43

0

Medium

No

No

Yes

No

Low

Fear of falling

3

101

33.6

− 1.04

− 2 to − 0.07

14.2% (p = 0.31)

Slightly Asym (p = 0.1)

− 1.04

0

Medium

No

No

Yes

No

Low

Gait speed

9

251

27.8

− 0.11

− 0.35 to 0.14

0% (p = 0.53)

Asym (p = 0.12)

− 0.06

46

Medium

No

No

Yes

Yes

Low

  1. Heter heterogeneity, K number of comparisons, N number of participants in each meta-analysis, Ns number of participants per study, SMD standardized mean difference, 95% CI 95% confidence interval, I2 degree of inconsistency, Adj adjusted, % var percentage of variation, Indirect indirectness, Imprec imprecision, Asym asymmetric, EC closed eyes, EO eyes open