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Table 3 Gait sequence detection (GSD) performance measures; gait sequence total duration obtained from the INDIP and the single wearable device, absolute error, bias and limits of agreement (LoA) and intra class correlation (ICC(2,1)) for comparison between systems, and overall performance index for the GSD algorithms. Values are expressed as mean and 95% confidence intervals (CI) for each cohort. In italic and boldface recommended algorithms. Underlined performance index indicates top-ranked algorithm for the specific cohort of that row

From: Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium

Cohort

Gait sequence detection

Gait sequence total duration

Performance index

Sensitivity

Positive predictive value

Accuracy

Specificity

INDIP mean and CI [s]

Single wearable device mean and CI [s]

Bias and LoA [s]

Absolute error [s]

ICC (2,1)

GSDA

 

 HA

0.84 [0.77, 0.92]

0.81 [0.75, 0.88]

0.94 [0.93, 0.96]

0.96 [0.95, 0.97]

1640.0 [1273.4, 2006.6]

1708.5 [1316.3, 2100.7]

68.5 [− 710.6, 847.5]

215.7 [57.7, 373.7]

0.88 [0.73, 0.95]

0.819

 CHF

0.85 [0.68, 1.01]

0.81 [0.72, 0.90]

0.95 [0.92, 0.98]

0.96 [0.94, 0.99]

1545.4 [421.1, 2669.6]

1595.4 [395.2, 2795.6]

50.0 [− 689.5, 789.5]

242.0 [39.6, 444.4]

0.98 [0.91, 0.99]

0.853

 COPD

0.85 [0.81, 0.88]

0.75 [0.68, 0.82]

0.95 [0.93, 0.97]

0.96 [0.95, 0.98]

1004.8 [829.2, 1180.4]

1151.6 [955.7, 1347.6]

146.8 [− 369.1, 662.8]

176.5 [51.5, 301.5]

0.68 [0.32, 0.87]

0.822

 MS

0.92 [0.87, 0.97]

0.75 [0.66, 0.84]

0.95 [0.92, 0.98]

0.95 [0.92, 0.98]

1119.5 [736.9, 1502.2]

1452.0 [990.4, 1913.6]

332.5 [− 883.9, 1548.8]

358.5 [57.7, 659.4]

0.68 [0.34, 0.87]

0.735

 PD

0.86 [0.78, 0.94]

0.81 [0.71, 0.91]

0.96 [0.95, 0.98]

0.97 [0.96, 0.99]

1121.8 [626.5, 1617.1]

1177.3 [656.2, 1698.5]

55.6 [− 402.4, 513.6]

139.1 [45.8, 232.4]

0.98 [0.94, 0.99]

0.852

 PFF

0.71 [0.54, 0.89]

0.74 [0.61, 0.88]

0.95 [0.92, 0.97]

0.97 [0.96, 0.99]

954.4 [599.5, 1309.4]

975.7 [589.8, 1361.6]

21.3 [− 365.3, 407.9]

144.4 [72.1, 216.7]

0.96 [0.89, 0.99]

0.770

GSDB

 

 HA

0.86 [0.82, 0.90]

0.85 [0.79, 0.92]

0.95 [0.94, 0.96]

0.97 [0.96, 0.98]

1645.8 [1258.1, 2033.5]

1657.4 [1283.5, 2031.3]

11.6 [− 592.4, 615.6]

170.5 [48.1, 292.8]

0.93 [0.83, 0.97]

0.727

 CHF

0.91 [0.88, 0.94]

0.82 [0.71, 0.92]

0.96 [0.94, 0.98]

0.96 [0.94, 0.99]

1545.4 [421.1, 2669.6]

1689.6 [557.8, 2821.5]

144.3 [− 331.8, 620.4]

176.1 [19.8, 332.3]

0.99 [0.95, 1.00]

0.792

 COPD

0.84 [0.81, 0.88]

0.80 [0.77, 0.82]

0.96 [0.95, 0.97]

0.97 [0.97, 0.98]

1004.8 [829.2, 1180.4]

1058.4 [865.5, 1251.4]

53.6 [− 120.3, 227.6]

71.9 [34.0, 109.8]

0.96 [0.90, 0.99]

0.814

 MS

0.91 [0.87, 0.95]

0.75 [0.65, 0.85]

0.95 [0.92, 0.98]

0.95 [0.92, 0.98]

1119.5 [736.9, 1502.2]

1416.3 [947.8, 1884.8]

296.8 [− 911.6, 1505.2]

323.1 [23.5, 622.6]

0.70 [0.38, 0.88]

0.655

 PD

0.84 [0.76, 0.92]

0.83 [0.73, 0.93]

0.96 [0.95, 0.97]

0.98 [0.96, 0.99]

1121.8 [626.5, 1617.1]

1145.9 [629.1, 1662.6]

24.1 [− 450.9, 499.0]

167.9 [85.1, 250.8]

0.97 [0.94, 0.99]

0.726

 PFF

0.73 [0.60, 0.86]

0.84 [0.76, 0.93]

0.96 [0.95, 0.98]

0.98 [0.97, 0.99]

911.7 [569.4, 1254.0]

861.1 [542.8, 1179.3]

− 50.7 [− 445.9, 344.6]

141.4 [62.2, 220.6]

0.95 [0.86, 0.98]

0.771

GSDC

 

 HA

0.77 [0.71, 0.83]

0.91 [0.85, 0.98]

0.95 [0.94, 0.96]

0.99 [0.98, 1.00]

1645.8 [1258.1, 2033.5]

1409.3 [1034.8, 1783.7]

− 236.5 [− 848.7, 375.7]

323.6 [220.1, 427.1]

0.88 [0.73, 0.95]

0.722

 CHF

0.84 [0.79, 0.88]

0.89 [0.82, 0.96]

0.97 [0.95, 0.98]

0.98 [0.97, 0.99]

1545.4 [421.1, 2669.6]

1466.6 [359.8, 2573.4]

− 78.7 [− 309.9, 152.4]

113.1 [55.1, 171.1]

1.00 [0.99, 1.00]

0.811

 COPD

0.73 [0.68, 0.78]

0.89 [0.87, 0.91]

0.96 [0.95, 0.97]

0.99 [0.99, 0.99]

1004.8 [829.2, 1180.4]

825.2 [664.4, 986.1]

− 179.6 [− 420.7, 61.6]

179.6 [116.3, 242.8]

0.80 [0.53, 0.92]

0.776

 MS

0.83 [0.77, 0.90]

0.83 [0.73, 0.93]

0.96 [0.93, 0.98]

0.97 [0.94, 1.00]

1119.5 [736.9, 1502.2]

1223.3 [794.0, 1652.5]

103.8 [− 1100.0, 1307.5]

246.9 [− 36.2, 530.0]

0.72 [0.41, 0.89]

0.693

 PD

0.76 [0.65, 0.87]

0.87 [0.76, 0.98]

0.96 [0.95, 0.97]

0.99 [0.98, 1.00]

1121.8 [626.5, 1617.1]

1000.4 [514.3, 1486.5]

− 121.4 [− 579.4, 336.5]

192.3 [107.3, 277.3]

0.97 [0.92, 0.99]

0.726

 PFF

0.60 [0.45, 0.75]

0.89 [0.77, 1.01]

0.94 [0.91, 0.97]

0.99 [0.99, 1.00]

954.4 [599.5, 1309.4]

697.3 [439.9, 954.8]

− 257.1 [− 823.6, 309.4]

272.4 [120.9, 423.9]

0.78 [0.47, 0.92]

0.687

  1. HA healthy adults; PD Parkinson’s disease; MS multiple sclerosis; COPD chronic obstructive pulmonary disease; CHF congestive heart failure; PFF proximal femoral fracture; CI confidence intervals, LoA limits of agreement, ICC intra class correlation