Fig. 4

Transcranial magnetic stimulation (TMS) results. A Example of the neuronavigation map obtained in a subject during recruitment curve measures. Heat map indicates consistent cortical location of successive stimulations during testing in one patient. This ensured stable cortical location of stimulation over left M1 (red area). Below, an example motor evoked potential in 1DI after single-pulse TMS (in black) and after paired-pulse (conditioned) stimulation (in grey). The difference in MEP size between single and paired pulse stimulations was used to calculate SICI%. B Change in SICI% after training (negative values depict reinforced inhibition). The majority of patients showed stronger SICI after training, and the degree of SICI% change correlated significantly with change in BBT (T1-T0; Spearman Rho = − 0.80, P = 0.006)