Table 2 Primary and secondary outcomes
|  | Conventional therapy | Dextrain therapy | Median of differences [CL95%]†| P value (Mood median test) |
|---|---|---|---|---|
Clinical assessments | ||||
BBT score (Primary outcome) (median [Q1 to Q3]) | ||||
Change from baseline (T0) | ||||
At post-training (T1) | 4 [2 to 7] | 5 [2 to 7] | 0.0 [− 3.0 to 2.0] | 0.36 |
At follow-up (T2) | 4 [1 to 12] | 8 [5 to 13] | 3.0 [− 1.0 to 7.0] | 0.06 |
Fmax% (median [Q1 to Q3]) | ||||
Change from baseline (T0) | ||||
At post-training (T1) | − 0.7 [− 5.5 to 5.7] | 4.2 [− 5.7 to 9.2] | 1.9 [− 4.6 to 9.4] |  |
At follow-up (T2) | 3.1 [− 2.1 to 9.6] | 8.8 [− 1.8 to 28] | 9.9 [− 7.7 to 20.1] |  |
MPUT time/item (median [Q1 to Q3]) | ||||
Change from baseline (T0) | ||||
At post-training (T1) | 0.5 [0.3 to 1.5] | 1 [0.4 to 2.9] | 0.3 [− 0.4 to 1.7] |  |
At follow-up (T2) | 0.7 [0.3 to 1.5] | 1.2 [0.3 to 3.1] | 0.1 [− 0.6 to 2.0] |  |
Light touch (median [Q1 to Q3]) | ||||
Change from baseline (T0) | ||||
At post-training (T1) | 0 [0 to 3] | 0 [0 to 5] | 0.0 [0.0 to 3.0] | 0.53 |
At follow-up (T2) | 0 [0 to 5] | 5 [0 to 8] | 3 [0.0 to 5.0] | 0.14 |
Max Tapping speed (mean [CI95%]) | ||||
Change from baseline (T0) | ||||
At post-training (T1) | 4.5 [2.3 to 6.7] | 8.4 [5.2 to 11.6] | 3.9 [0.0 to 7.7] | 0.045* |
At follow-up (T2) | 7.3 [2.5 to 12.1] | 10.6 [3.3 to 17.9] | 3.3 [− 5.6 to 12.1] |  |
MAL AOU (median [Q1 to Q3]) | ||||
Change from baseline (T0) | ||||
At post-training (T1) | 0.3 [0.0 to 0. 7] | 0.3 [0.1 to 0.7] | 0.1 [− 0.2 to 0.3] |  |
At follow-up (T2) | 0.2 [0.1 to 0.6] | 0.7 [0.2 to 0.8] | 0.5 [0.0 to 0.7] | 0.05* |
MAL QOM (median [Q1 to Q3]) | ||||
Change from baseline (T0) | ||||
At post-training (T1) | 0.1 [0.0 to 0.5] | 0.3 [0.1 to 0.6] | 0.1 [− 0.1 to 0.4] |  |
At follow-up (T2) | 0.3 [0.0 to 0.6] | 0.7 [0.2 to 0.8] | 0.2 [− 0.1 to 0.7] |  |
ARAT (median [Q1 to Q3]) | ||||
Change from baseline (T0) | ||||
At post-training (T1) | 2 [0 to 4] | 3 [1 to 5] | 0.0 [− 1.0 to 2.0] |  |
At follow-up (T2) | 2 [0 to 4] | 3 [0 to 7] | 0.0 [− 2.0 to 5.0] |  |
Dextrain components | ||||
Tracking Error (mean [CI95%]) | ||||
Change from baseline (T0) | ||||
At post-training (T1) | − 0.1 [− 0.2 to 0.1] | 0.3 [0.2 to 0.4] | 0.4 [0.1 to 0.6] | 0.0008* |
At follow-up (T2) | 0.0 [− 0.1 to 0.2] | 0.2 [0.0 to 0.4] | 0.2 [0.0 to 0.4] | 0.06 |
Multi-finger Tapping (independence of finger movements) | ||||
Success rate (mean [CI95%]) | ||||
Change from baseline (T0) | ||||
At post-training (T1) | 0.0 [0.0 to − 0.1] | 0.1 [0.0 to 0.2] | 0.1 [0.0 to 0.2] | 0.27 |
At follow-up (T2) | 0.1 [0.0 to 0.2] | 0.1 [− 0.1 to 0.3] | 0.0 [− 0.2 to 0.3] |  |
Reaction Time (mean [CI95%]) | ||||
Change from baseline (T0) | ||||
At post-training (T1) | 7.7 [− 9.5 to 24.8] | 34.7 [20.2 to 49.2] | 29.9 [15 to 44.9] | 0.02* |
At follow-up (T2) | 2.1 [− 26.8 to 31.1] | 30.1 [6.1 to 55.1] | 27.5 [4.8 to 50.3] | 0.08 |
Rhythm 3Â Hz (mean [CI95%]) | ||||
Change from baseline (T0) | ||||
At post-training (T1) | 0.1 [− 9.9 to 10] | 0.4 [− 3.6 to 4.5] | 0.4 [− 10 to 10.8] |  |
At follow-up (T2) | − 0.8 [− 16.4 to 14.8] | − 4.5 [− 13.1 to 4.1] | − 3.8 [− 22.2 to 14.6] |  |