Study (year) | Country | Sex (male/female) | Age | Hoehn and Yahr stage | Intervention | Intervention protocol | Supervision, supervisior | Related outcome measures | P value | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EG | CG | EG | CG | EG | CG | EG | CG | ||||||
Kashif (2022) [24] | Pakistan | 13/9 | 12/10 | 63.86 ± 4.57 | 62.32 ± 4.61 | 2.11 ± 0.74 | 2.25 ± 0.67 | Physical therapy + virtual reality (Nintendo Wii) + motor imagery | Physical therapy | 60 min/d 3 d/wk 6, 12 wks Follow-up to 16 wks | Full, physical therapist | UPDRS II | < 0.001 |
UPDRS III | < 0.001 | ||||||||||||
BBS | < 0.001 | ||||||||||||
ABC | < 0.001 | ||||||||||||
Pazzaglia (2020) [25] | Italy | 18/7 | 17/9 | 72 ± 7 | 70 ± 10 | NR | NR | Virtual reality (NIRVANA) | Physical therapy | 40 min/d 3 d/wk 6 wks | Full, physical therapist | BBS | NR |
DGI | NR | ||||||||||||
Santos (2019) [26] | Brazil | 11/2 | 11/3 | 61.7 ± 7.3 | 64.5 ± 9.8 | 1.4 ± 0.6 | 1.3 ± 0.3 | Virtual reality (Nintendo Wii) | Conventional exercise | 50 min/d 2 d/wk 8 wks | Full, physiotherapist | BBS | 0.968 |
DGI | 0.277 | ||||||||||||
9/5 | 66.6 ± 8.2 | 1.5 ± 0.4 | Virtual reality (Nintendo Wii) + conventional exercise | TUGT | 0.824 | ||||||||
PDQ-39 | 0.331 | ||||||||||||
Feng (2019) [27] | China | 8/7 | 9/6 | 67.47 ± 4.79 | 66.93 ± 4.64 | 3.03 ± 0.55 | 2.97 ± 0.58 | Virtual reality | Physical therapy | 45 min/d 5 d/wk 12 wks | Full, physical therapist | BBS | NR |
TUGT | NR | ||||||||||||
UPDRS III | NR | ||||||||||||
FGA | NR | ||||||||||||
Ferraz (2018) [28] | Brazil | 10/10 | 16/6 | 67 (66–68) | 71 (66–75) | 2.5 (2.0–2.5) | 2.5 (2.5–3.0) | Virtual reality (Xbox 360 with Kinect) | Functional training | 50 min/d 3 d/wk 8 wks | Full, physiotherapist | 6MWT | NS |
10MWT | NS | ||||||||||||
11/9 | 67 (64–71) | 2.5 (2.0–3.0) | Bicycle exercise | ||||||||||
PDQ-39 | NS | ||||||||||||
Ribas (2017) [29] | Brazil | 4/6 | 4/6 | 61.70 ± 6.83 | 60.20 ± 11.29 | 1.25 (1–2) | 1.5 (1–2) | Virtual reality (Nintendo Wii) | Conventional exercise | 30 min/d 2 d/wk 12 wks 60d follow-up | Full, physiotherapist | BBS | 0.043 |
6MWT | 0.023 | ||||||||||||
Gandolfi (2017) [30] | Italy | 23/15 | 28/10 | 67.45 (7.18) | 69.84 (9.41) | 2.5 (2.5–2.5) | 2.5 (2.5–3.0) | Virtual reality (Nintendo Tele Wii) | Sensory integration balance training | 50 min/d 3 d/wk 7 wks 1-month follow-up | Full, physiotherapist | BBS | 0.02 |
ABC | NS | ||||||||||||
10MWT | NS | ||||||||||||
DGI | NS | ||||||||||||
Carpinella (2017) [31] | Italy | 14/3 | 9/11 | 73.0 ± 7.1 | 75.6 ± 8.2 | 2.7 ± 0.7 | 2.9 ± 0.5 | Gamepad-based training | Physiotherapy | 45 min/d 3 d/wk 7 wks 1-month follow-up | Full, physiotherapist | BBS | 0.047 |
10MWT | 0.335 | ||||||||||||
TUGT | 0.269 | ||||||||||||
UPDRS III | 0.545 | ||||||||||||
ABC | 0.186 | ||||||||||||
FOG-Q | 0.695 | ||||||||||||
PDQ-39 | 0.844 | ||||||||||||
Yang (2016) [32] | Taiwan | 7/4 | 7/5 | 72.5 ± 8.4 | 75.4 ± 6.3 | 3(3–3) | 3(3–3) | VR balance training | Conventional balance training | 50 min/d 2 d/wk 6 wks Follow-up to 8 wks | Full, physiotherapist | BBS | 0.893 |
DGI | 0.970 | ||||||||||||
PDQ-39 | 0.684 | ||||||||||||
UPDRS III | 0.345 | ||||||||||||
Shih (2016) [33] | Taiwan | 9/1 | 7/3 | 67.5 ± 9.96 | 68.8 ± 9.67 | 1.6 ± 0.84 | 1.4 ± 0.52 | Balance-based exergaming with Kinect | Conventional balance training | 50 min/d 2 d/wk 8 wks | Not clear | BBS | NS |
TUGT | NS | ||||||||||||
Liao (2015) [34] | Taiwan | 6/6 | 6/6 | 67.3 ± 7.1 | 65.1 ± 6.7 | 2.0 ± 0.7 | 2.0 ± 0.8 | Virtual reality (Nintendo Wii) | Traditional exercise | 45 min/d 2 d/wk 6 wks 1-month follow-up | Not clear | TUGT | < 0.01 |
PDQ-39 | < 0.01 | ||||||||||||
van den Heuvel (2014) [35] | Netherland | 12/5 | 8/8 | 66.3 ± 6.39 | 68.8 ± 9.68 | 2.5 (2.0–2.5) | 2.5 (2.0–3.0) | Visual feedback training | Conventional balance training | 60 min/d 2 d/wk 5 wks follow-up to 12 wks | Full, physical therapist | BBS | 0.108 |
10MWT | 0.171 | ||||||||||||
UPDRS III | 0.021 | ||||||||||||
PDQ-39 | 0.444 | ||||||||||||
Pedreira (2013) [36] | Brazil | 11/5 | 11/4 | 61.1 ± 8.2 | 66.2 ± 8.5 | 2.5 ± 0.6 | 2.4 ± 0.7 | Virtual reality (Nintendo Wii) | Physical therapy | 40 min/d 3 d/wk 4 wks | Not clear | PDQ-39 | NR |
Pompeu (2012) [37] | Brazil | NR | NR | 67.4 ± 8.1 | 66.2 ± 8.3 | 1–2 | 1–2 | Wii-based motor and cognitive training | Global and balance exercise | 60 min/d 2 d/wk 7 wks 60d follow-up | Full, physiotherapist | UPDRS II | NS |
BBS | NS |