Table 5 Steps for the selection of predictor(s) and evaluation of the model

Steps for selecting the predictor(s)

1.  Run Lasso on 1000 bootstrap samples (Bolasso)

     1.1.  Select n-3 subjects without replacement at every run

     1.2.  For every subject, select randomly either observation from visit 2 or observation from visit 3

     1.3.  Run Lasso on the selected sample and save the vector of coefficients β

2.  Select all the variables with coefficient ≠ 0 in ≥ 60% of the cases

Steps for bootstrap evaluation of the model

3.  Run fitlm on 1000 bootstrap samples

     3.1.  Select n-3 subjects without replacement at every run

     3.2.  For every subject, select randomly either observation from visit 2 or observation from visit 3

     3.3.  Run fitlm on the selected sample and save β, Adj. R² and residuals

4.  Calculate the average model coefficients β and their CI, the CI of the mean and the PI for new observations