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Table 4 Sensory and pain: state-of-the-art and future directions

From: NSF DARE—transforming modeling in neurorehabilitation: a patient-in-the-loop framework

State-of-the-art

a. Separate models for typical development and for specific neurodevelopmental

and neurodegenerative conditions.

b. Experimental paradigms and models that constrain dimensionality.

Future directions

a. Multisensory models that consider feedforward and feedback mechanisms.

b. Sensitive and specific diagnostic models that account for general population

variability and phenotypic heterogeneity within conditions.

c. High-dimensional diagnostic and treatment models that account for interplay

between physiological, cognitive, emotional, and behavioral factors to support

optimization and personalization.