Somatotopical feedback versus non-somatotopical feedback for phantom digit sensation on amputees using electrotactile stimulation
© Zhang et al.; licensee BioMed Central. 2015
Received: 29 November 2014
Accepted: 17 April 2015
Published: 2 May 2015
Transcutaneous electrical stimulation can provide amputees with tactile feedback for better manipulating an advanced prosthesis. In general, there are two ways to transfer the stimulus to the skin: somatotopical feedback (SF) that stimulates the phantom digit somatotopy on the stump and non-somatotopical feedback (NF) that stimulates other positions on the human body.
To investigate the difference between SF and NF, electrotactile experiments were conducted on seven amputees. Electrical stimulation was applied via a complete phantom map to the residual limb (SF) and to the upper arm (NF) separately. The behavior results of discrimination accuracy and response time were used to examine: 1) performance differences between SF and NF for discriminating position, type and strength of tactile feedback; 2) performance differences between SF and NF for one channel (1C), three channels (3C), and five channels (5C). NASA-TLX standardized testing was used to determine differences in mental workload between SF and NF.
The grand-averaged discrimination accuracy for SF was 6% higher than NF, and the average response time for SF was 600 ms faster than NF. SF is better than NF for position, type, strength, and the overall modality regarding both accuracy and response time except for 1C modality (p<0.001). Among the six modalities of stimulation channels, performance of 1C/SF was the best, which was similar to that of 1C/NF and 3C/SF; performance of 3C/NF was similar to that of 5C/SF; performance of 5C/NF was the worst. NASA-TLX scores indicated that mental workload increased as the number of stimulation channels increased.
We quantified the difference between SF and NF, and the influence of different number of stimulation channels. SF was better than NF in general, but the practical issues such as the limited area of stumps could constrain the use of SF. We found that more channels increased the amount and richness of information to the amputee while fewer channels resulted in higher performance, and thus the 3C/SF modality was a good compromise. Based on this study, we provide possible solutions to the practical problems involving the implementation of tactile feedback for amputees. These results are expected to promote the application of SF and NF tactile feedback for amputees in the future.
KeywordsElectrotactile stimulation Phantom digit somatotopy Somatotopical feedback Non-Somatotopical feedback Amputees
Currently, vision is the predominant feedback for upper limb amputees to control prosthetic hands, while tactile feedback is conspicuously missing in practical applications [1-3]. This results in high mental workload for amputees and impairs the ability of amputees to control advanced prosthetic hands of high dexterity . Researchers have been investigating the use of artificial stimulation for providing amputees with tactile feedback information, in order to achieve more dexterous prosthetic control while reducing the mental load of users. Electrotactile stimulation can stimulate afferent receptors in the skin, resulting in perceived sensations like vibration, pressure, and slipping [5-7]. Besides prosthesis, electrotactile stimulation has been widely used in other fields such as tactile sensory substitution, teleoperation, robotics, and virtual reality [8-10].
Artificial tactile feedback can be delivered to amputees in two ways: somatotopical feedback (SF) that stimulates the phantom digit somatotopy on the stump [11-16] and non-somatotopical feedback (NF) that stimulates other positions on the body [17-22]. Most researchers choose NF to deliver tactile sensory information and stimulate some ordinary sites such as forearm [18,21,23-25], lower back [20,26], or other places on the body . Though some researchers stimulate the stump to deliver tactile feedback, they typically choose positions that have two-point discrimination, rather than positions that have certain phantom digit somatotopy [12,14]. Recent research has shown that some forearm amputees have phantom hand sensations causing them to feel that their fingers or other parts of the missing hand are being touched when some areas of their stumps are touched [27,28]. However, there are few studies that utilize SF for closed-loop prosthetic control . Thus, differences between SF and NF have not been investigated. Therefore, it is important to quantify the difference between NF and SF based on a thorough comparative study. Further, many researchers have analyzed the tactile sensory ability of subjects based on five channels for five fingers [12,14,16,18,19,21,23,24,29]. Due to practical concerns, a balance between rich feedback information and high performance is needed. It means that some channels need to be removed to achieve better discrimination performance of tactile feedback. In addition, a majority of studies have investigated the behavior of able-bodied subjects for providing amputees with tactile feedback [19,20,24,25]. However, differences between intact-limbed persons and amputees in perceiving, interpreting and utilizing artificial tactile feedback are significant. Finally, current methods typically only examine discrimination accuracy on different sensations, and rarely analyze the response time and the user’s mental workload .
To comprehensively compare SF and NF on transradial amputees, we investigate the following three aspects based on electrotactile stimulation. First, NF requires forearm amputees to “learn” the new mapping between finger tactile sensation and unrelated skin areas (e.g. upper arm), while SF exploits the remaining mapping of amputees. The key question is what the difference is between the two mental tasks in the context of prosthetic control. To answer this question, this study quantitatively investigates the different effects between SF and NF in discriminating multi-position, multi-type and multi-strength electrotactile sensations on seven transradial amputees. Second, this study aims to analyze the performance differences between SF and NF under different numbers of stimulation channels. Third, we investigate the mental workload of the amputees using SF and NF based on the NASA-TLX self-assessment questionnaire.
In this work, we evaluate the performance of multi-position, multi-type, and multi-strength electrotactile stimulation on SF and NF with different numbers of channels, and provide suggestions and guidelines for implementing artificial electrotactile feedback for amputees.
Material and methods
R. mid third (15)
Half day, myoelectric
R. lower third (23)
All day, cosmetic
R. upper third (8)
All day, cosmetic
L. mid third (16)
Half day, cosmetic
L. mid third (17)
Half day, cosmetic
R. mid third (19)
All day, myoelectric
L. upper third (10)
Half day, myoelectric
The stimulation interface is a kind of custom-made electrode array with nine copper bars (Figure 1-E). To prevent chemical reactions during electrical stimulation and decrease the possibility of pricking sensations due to electric charge accumulation, the copper bars are covered with hydrogel. For the electrode array, the upper three copper bars are connected to the anode/cathode of the stimulator, the lower three copper bars are connected to the ground of the stimulator, and the middle three copper bars are not used in this work. All the copper bars do not share the same ground to prevent possible interference from the adjacent bars.
A pilot test was conducted before the main experiment, and all subjects performed the following tasks.
Position selection of SF and NF
The NF sites were chosen on the ipsilateral upper arm, not on the stump. Because all subjects had a somatotopical map on the stumps, the area left for NF was much smaller. Taking subject 3 as an example, her stump length was just 8 cm, and nearly all the area of her stump was occupied by the somatotopical map, so we could not find enough area for NF (5 channels). Even if enough area for NF could be found on the stump of some subjects, it was easy to mix with the SF area. Some subjects could not distinguish the exact boundaries clearly, thus the comparison between NF and SF would not be convincible in such case. In the end, the NF areas were selected on the upper arm for all subjects to maintain consistency. If NF was chosen on the stump for some subjects, while NF was chosen on the upper arm for other subjects, the comparison between NF and SF on different subjects would be not fair and just.
Two-point discrimination assessment on NF
Stimulation current was set as monophasic and rectangular pulses. The amplitude of current was chosen to about 1.5mA, and was adjusted to assure the same perceived sensation to each subjects with the help of a psychophysical method (visual analog scale) . For the pressure sensation, the stimulation current was negative, and we chose 100Hz as the stimulating frequency [31-33]. The subjects reported that the 100Hz-stimulation elicited a well-localized, continuous sensation resembling constant pressure on the surface of skin. Then we changed the pulse width from 0 to 500 μs . We recorded the minimum pulse width (P W min) for the subject when he reported the feeling of touch, and recorded the maximum pulse width (P W max) for the subject when he reported the feeling of pricking. For the vibration sensation, the current direction was positive. It was known that the strength of feeling was related to the velocity of vibration. Thus, we chose half of the maximum pulse width as the constant, and then changed the frequency from 1 to 75Hz (the current direction is positive) [31-33]. The maximum frequency (f max) was recorded for the subject when he reported that he/she couldn’t discriminate the interval of the pulses. This procedure was repeated three times in succession.
Setting of stimulating parameters
20% f max
50% f max
50% P W max
80% f max
20% P W max
50% P W max
80% P W max
Stimulation at different positions of SF or NF can elicit sensations of different phantom digits. In daily life, the thumb, index finger, and middle finger are used more frequently, while the ring finger and little figure are used less often. In order to reduce the experimental time for the amputees, not all combinations of five channels were considered. Instead, we chose one channel (1C), three channels (3C), and five channels (5C) for phantom digit sensations. For SF, 1C targeted the phantom thumb; 3C targeted the phantom thumb, index finger, and middle finger; 5C targeted all of the five phantom digits. For NF, the five positions were equally distributed around the circumference of the upper arm 6 cm above the elbow joint. 1C was in the middle of the glabrous area; 3C targeted three positions in the glabrous area; 5C targeted all the five positions on the circle of NF. Thus, there were six modalities of the stimulating channels for SF and NF, and we performed six experiments accordingly.
During each experiment, the subject wore a headset (Philips, Netherlands), which was used to receive a beep at the beginning of each trial (see Figure 1). Once the subject could identify position, type and strength of sensation for each stimulation, he pressed a control button of the keyboard by himself to stop the stimulation and make the computer record the trial’s response time. Then the subject verbally reported the answer to the experimenter. The experimenter input the subject’s answer to the computer and began the next trial. At the end of every experiment, the subject filled out a NASA-TLX questionnaire. The experimenter did not reveal the correct answer about the stimulation pattern to the subject in the experiments.
Experiment 1–1C for SF (1C/SF)
One-channel stimulation was performed. There were 21 (the channel could be enabled or disabled) possible options for the evaluation index “position”, 2 possible options (pressure or vibration) for “type” and 3 possible options (weak, medium, or strong) for “strength”. Altogether, one session included 12 (21∗2∗3=12) trials. There were four sessions, 48 trials (12∗4=48), and the overall duration lasted about 4 minutes.
Experiment 2–3C for SF (3C/SF)
Three-channel stimulation was performed. There were 23 (each channel could be enabled or disabled) possible options for “position”, 2 possible options for “type” and 3 possible options for “strength”. Altogether, one session included 48 (23∗2∗3=48) trials. There were four sessions, 192 trials (48∗4=192), and the overall duration of experiment 2 lasted about 18 minutes.
Experiment 3–5C for SF (5C/SF)
Five-channel stimulation was performed. There were 25 (each channel could be enabled or disabled) possible options for “position”, 2 possible options for “type” and 3 possible options for “strength”. Altogether, one session included 192 (25∗2∗3=192) trials. There were four sessions, 768 trials (192∗4=768), and the overall duration of experiment 3 was about 1–1.5 hours.
Experiments 4, 5, 6 (1C/NF, 3C/NF, 5C/NF)
Experiments 4, 5, 6 were for NF, which were similar to experiments 1, 2, 3 respectively. The only difference was that the stimulating positions were changed from the stump (SF) to the ipsilateral upper arm (NF).
Four-way ANOVA was applied first, which had four factors: Feedback Site (SF, NF), Channel (1C, 3C, 5C), Type (pressure, vibration), Strength (low, medium, high). There were no other main-effect factors. Please note that “Position” indicated the positions of skin being stimulated, where the activated channels were applied. In other words, “Position” was a representation of the activated channels. Since channel was an effect already, “Position” was not considered any more. The “Subject” was a within-subjects factor, and the main effect of subject factor was not significant. It meant that successful accuracy and response time across experimental tasks were fully determined by the levels of the between-subjects factors, whereas the level of subject factor did not have a relevant influence. The results revealed that only the “Feedback Site (SF, NF)” and the “Channel (1C, 3C, 5C)” had interactions (p<0.05). Therefore, Type (pressure, vibration) and Strength (low, medium, high) were pooled across “Feedback Site” and “Channel”.
Since Feedback Site (SF, NF) and Channel (1C, 3C, 5C) had interactions, we used a simple-effect analysis to break down the ANOVA further into subsequent one-way ANOVA. The channel effects were analyzed for SF and NF, respectively. In SF, one-way ANOVA was used and the only factor was “Channel (1C, 3C, 5C)”, which was the same as that in NF. Feedback Site effects were analyzed for three channel conditions (1C, 3C, 5C), respectively, and one-way ANOVA was also used where the only factor was the “Feedback Site (SF, NF)”. Statistical significance was set to the level of p<0.05. We used the Bonferroni correction to do the post hoc pairwise comparisons. The p-values should be adjusted for multiple comparisons. For example, comparing the effects of different numbers of channels on SF and NF, the p-value should be adjusted to 0.05/3, and it was the same for the results of NASA-TLX.
Comparison between SF and NF
Comparison among different numbers of channels
There were 15 pairwise comparisons on the performance of the six experiments. Within SF (1C, 3C, 5C), there were 3 pairwise comparisons, which was the same as that within NF (1C, 3C, 5C). There were 9 pairwise comparisons between SF and NF. The ANOVA results showed no statistically significant differences (p > 0.05) between 1C of SF and 3C of SF, 1C of SF and 1C of NF, 3C of SF and 1C of NF, 5C of SF and 3C of NF. Except for the above 4 pairs, all of the other 11 pairs were statistically different (p < 0.01).
General difference between SF and NF
Conventional theory of somatotopical mapping states that the sensitivity of touch sensation in different areas of the body is mainly due to the mechanoreceptor density in skin or the convergence effect of dorsal column nuclei (DCN) in the brainstem. The two-point discrimination assessment has shown that the forearm and upper arm of able-bodied subjects have similar tactile sensitivity . However, the result of Figure 4 shows a large difference (11.17%) between SF (forearm) and NF (upper arm) on position discrimination, which cannot be explained by this conventional theory. The reason for the difference in position discrimination between SF and NF should be the effect of phantom digits. This means that some amputees feel their “original fingers” are touched when experimenters touch some specific parts of their stumps, and the tactile sensitivity of phantom fingers is better than arm.
Currently, some researchers have explained the phantom digit phenomenon in two ways [15,28,38]. First, with respect to peripheral nerve, the affected nerves that once deliver tactile information of fingers are attached to the tissue of the stump by suture during the amputation surgery. Some nerves may connect with the tactile receptors in the skin of stump. Thus, the tactile feedback channels have been reconstructed and amputees have phantom fingers. Second, with respect to the somatosensory cortex, the cortex that once represented the digits, hand or forearm region may be replaced by other parts of human body, such as the face, chest and stump. Thus, an amputee, whose cortex of the amputated hand is invaded by that of the stump, may also have phantom digits when his stump is touched.
For SF, when we deliver the tactile stimulation to the somatotopical positions on the subject’s amputated stump, it’s likely to stimulate the phantom digits. The ability of the amputees to discriminate positions is similar to that of the able-bodied. For NF, however, the stimulating positions are common places on the upper arm, which need subjects to set up the new mapping between the stimulating positions and specific fingers. It seems that the subjects should “learn” a technique that they are not familiar with, so they would feel confused when the stimulation channels are increased. Thus, the discrimination of position unquestionably deteriorates. That may be the cause of the different position’s discrimination between SF and NF.
The other performance of SF (type discrimination, strength discrimination, and response time) is also better than that of NF. The NASA-TLX questionnaire can provide some clues of the reason. We can see that the average NASA-TLX index by SF (65.87%) is less than NF (70.77%). This indicates that SF requires lower mental workload. On the contrary, it is harder and slower for the amputees to discriminate the stimulating modalities of NF.
Influence of different numbers of channels
Behavior results among different numbers of channels are shown in Figure 5, and some interesting phenomena are discovered. For SF, since there is no statistically significant difference between 1C and 3C, it can be concluded that the ability of discriminating different stimulating modalities is nearly the same for the condition of fewer stimulation channels among the subjects. The cause of this surprising phenomenon may be that when one or three positions on the phantom digit mapping area are stimulated, it just looks like the corresponding real fingers (1 finger or 3 fingers) are stimulated. The mapping is strong and the mental burden is small, so the two stimulating modalities (1C and 3C) show similar results. But there is a statistically significant difference between 3C and 5C modalities. Despite the fact that 5C modality may also have a strong mapping of phantom digits, the distribution of current generated by five electrodes may interact, due to the small stimulation region. This may be a possible reason for the deteriorated performance on 5C of SF. There is further evidence from NASA-TLX index, which shows that 5C (69.33%) is greater than 3C (64.81%) (see Figure 6). This indicates that the 5C modality takes more mental workload. Thus, these two possible reasons might explain why the performance of the 5C modality was the worst.
For NF, there is a general deterioration in the accuracy and response time as the number of channels increases (p < 0.001). The more channels involved, the more attention is needed and this leads to more mistakes. Surprisingly, 1C of NF, 1C of SF, and 3C of SF are not statistically different. The reason for the similarity between 1C of NF and that of SF may be that the subjects only need to discriminate the type and strength of the stimulation without considering the stimulating position (there is only one stimulation channel). Thus, the discrimination ability on the type and strength between SF and NF does not make a difference.
Thus, if we have to seek a balance between good performance and rich sensation for electrotactile stimulation, some channels may be reduced leaving 3C/SF as the best choice.
Pros and cons
This work does not aim to simply confirm that SF is superior to NF. We hope these results are helpful for the application of SF and NF. For some practical concerns about myoelectric controlled prosthesis, there are two problems: 1) some amputees do not have the phantom digit sensation, and we cannot provide the SF for amputees; 2) the area of stump is extremely valuable, and it can be a significant problem to arrange many electromyography (EMG) electrodes and electrical stimulation electrodes together.
Practical problems and solutions about tactile feedback for amputees
Phantom digit sensation
Area of stump
3C of SF
1C of NF, or 3C of NF,
hybrid SF and NF
1C of NF, or 3C of NF
Specifically, when the demand of rich tactile information is high (the number of feedback channels must be 5 like five digits of a human hand) in condition 3, the only solution is to choose 5C/NF. Certainly, someone may question 5C/NF for the poor performance. However, our preliminary study has shown that reinforced learning (or training) for the amputees can improve the performance of NF. This indicates that the NF may show the similar performance as the SF, but it will require long training time and heavy mental workload. Future work will investigate challenges of reinforced learning and optimization for NF application.
This work investigated multi-position, multi-type and multi-strength electrotactile feedback for amputees, towards closed-loop control of prosthesis in application. We focused on the difference between SF and NF, and the influence of different number of channels for tactile feedback. Through the study, we found that SF had better performance than NF in general. Furthermore, considering the subject’s behavior result and the task loading acquired from the NASA-TLX questionnaire, we recommend tactile feedback for three phantom digits as a good trade-off between better performance and more sensation information. Based on the results and analysis, we have provided possible solutions for solving practical problems about providing tactile feedback for amputees.
This research was supported by the National Basic Research Program (973 program) of China (2011CB013305), the National Natural Science Foundation of China (No. 51475292), and the Natural Science Foundation of Shanghai (14ZR1421300).
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